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Title:
SURFACE-MODIFIED TITANIUM DIOXIDE FINE PARTICLES AND DISPERSION COMPRISING THE SAME, AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/087577
Kind Code:
A1
Abstract:
Surface-modified titanium dioxide fine particles which have a surface chemically modified with a hydrophilic polymer, wherein a carboxyl group of the hydrophilic polymer and titanium dioxide are bound through an ester bonding; and a method for producing the surface-modified titanium dioxide fine particles, which comprises mixing a dispersion comprising titanium dioxide fine particles having a particle size of 2 to 200 nm and a solution of a water-soluble polymer, heating the resultant mixture to a temperature of 80 to 220°C, to thereby bind both the components through an ester bonding, and removing an unbound water-soluble polymer, to purify the resultant particles. The surface -modified titanium dioxide fine particles exhibit excellent dispersibility and stability in an aqueous solvent over a wide pH region including a neutral range.

Inventors:
SONEZAKI SHUJI (JP)
BANZAI TOSHIAKI (JP)
KANEHIRA KOKI (JP)
YAGI SHINICHI (JP)
OGAMI YUMI (JP)
Application Number:
PCT/JP2004/004635
Publication Date:
October 14, 2004
Filing Date:
March 31, 2004
Export Citation:
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Assignee:
TOTO LTD (JP)
SONEZAKI SHUJI (JP)
BANZAI TOSHIAKI (JP)
KANEHIRA KOKI (JP)
YAGI SHINICHI (JP)
OGAMI YUMI (JP)
International Classes:
A61K33/24; A61K41/00; B01J31/06; B01J35/00; C09C1/36; C02F1/30; C02F1/32; (IPC1-7): C01G23/047; A61K33/00; A61K41/00; A61K47/48; A61K47/02; B01J35/02
Foreign References:
JPH1067516A1998-03-10
JP2002316946A2002-10-31
JP2002316950A2002-10-31
JP2002316946A2002-10-31
JP2002316950A2002-10-31
Other References:
R. CAI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 2346 - 2348
FX PERRIN, POLYM INT, vol. 51, 2002, pages 1013 - 1022
See also references of EP 1630136A4
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