Title:
A SUSPENSION COMPRISING FIBRINOGEN, THROMBIN AND ALCOHOL AND A METHOD OF COATING A CARRIER WITH THE SAME
Document Type and Number:
WIPO Patent Application WO2002058750
Kind Code:
A8
Abstract:
A suspension of fibrinogen, thrombin, alcohol and optionally aprotinin is obtained by mixing fibrinogen in alcohol with thrombin in alcohol. The suspension contains fibrinogen and thrombin particles with a Folk Ward mean diameter of 25 - 100 ñm. The thrombin may be human, bovine or recombinant. The fibrinogen may be human or recombinant. A method for coating a carrier, such as a collagen sponge, with the suspension, and a method for drying the coating is disclosed. The coated collagen carrier may be used as a ready-to-use absorbable composition for tissue gluing, tissue sealing and haemostasis wherein the carrier is coated with solidly fixed components of fibrin glue, i.e. fibrinogen and thrombin.
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Inventors:
SCHAUFLER ALFRED (AT)
Application Number:
PCT/IB2002/001454
Publication Date:
March 11, 2004
Filing Date:
January 25, 2002
Export Citation:
Assignee:
NYCOMED PHARMA AS (NO)
SCHAUFLER ALFRED (AT)
SCHAUFLER ALFRED (AT)
International Classes:
A61K38/46; A61K38/48; A61K9/16; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61L15/16; A61L15/22; A61L15/32; A61L15/42; A61L15/44; A61L15/64; A61L24/00; A61L24/08; A61L24/10; A61L27/00; A61L31/04; A61P7/04; A61P41/00; C08H1/06; C08J9/30; C08L89/06; A61L; C08J; C08L; (IPC1-7): A61L24/10; A61L15/32
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