Title:
SUSTAINED ANALGESIA ACHIEVED WITH BUPRENORPHINE
Document Type and Number:
WIPO Patent Application WO1998036728
Kind Code:
A3
Abstract:
A sustained release formulation of buprenorphine is new. The composition comprises a transdermal delivery device which provides a first order release of buprenorphine over a 3-day dosing interval so that a maximum plasma concentration of 20 10 1052 pg/ml is obtained. the device then provides zero order kinetics over at least 2 more days.
Inventors:
REDER ROBERT F (US)
GOLDENHEIM PAUL D (US)
GOLDENHEIM PAUL D (US)
Application Number:
PCT/US1998/003584
Publication Date:
December 10, 1998
Filing Date:
February 24, 1998
Export Citation:
Assignee:
EURO CELTIQUE SA (LU)
REDER ROBERT F (LU)
GOLDENHEIM PAUL D (LU)
REDER ROBERT F (LU)
GOLDENHEIM PAUL D (LU)
International Classes:
A61F13/00; A61K9/22; A61K9/70; A61K31/00; A61K31/485; A61P25/00; A61P29/00; (IPC1-7): A61K/
Foreign References:
| US5026556A | 1991-06-25 | |||
| US5069909A | 1991-12-03 | |||
| US5225199A | 1993-07-06 | |||
| US5240711A | 1993-08-31 | |||
| US5486362A | 1996-01-23 | |||
| US5132115A | 1992-07-21 | |||
| US4906463A | 1990-03-06 |
Other References:
See also references of EP 0964677A4
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