SUSTAINED-RELEASE LIPID PRE-CONCENTRATE OF GNRH ANALOGUES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Title:

SUSTAINED-RELEASE LIPID PRE-CONCENTRATE OF GNRH ANALOGUES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2014/104791

Kind Code:

A1

Abstract:

Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups; b) at least one phospholipid; c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety; and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.

Inventors:

YOON SANG PHIL (KR)
KO KI SEONG (KR)
YU HA NA (KR)
BAIK HYE JUNG (KR)
YANG WON KYU (KR)
KO JIN YOUNG (KR)
PARK SO HYUN (KR)
JUNG SUNG BUM (KR)
AN SUNG WON (KR)
KI MIN HYO (KR)

Application Number:

PCT/KR2013/012269

Publication Date:

July 03, 2014

Filing Date:

December 27, 2013

Export Citation:

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Assignee:

CHONG KUN DANG PHARM CORP (KR)

International Classes:

A61K9/20; A61K9/06; A61K9/08; A61K47/30

Foreign References:

US20070080323A1	2007-04-12
US20120269772A1	2012-10-25
US20080274176A1	2008-11-06
US5807573A	1998-09-15
US20110091420A1	2011-04-21

Other References: