SUSTAINED RELEASE-MICROSPHERE FORMULATION COMPRISING SEMAGLUTIDE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PREPARATION METHOD THEREFOR

Title:

SUSTAINED RELEASE-MICROSPHERE FORMULATION COMPRISING SEMAGLUTIDE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2024/010379

Kind Code:

A1

Abstract:

The present invention relates to a pharmaceutical composition that contains sustained-release microspheres composed of semaglutide or a pharmacologically acceptable salt thereof, a bioavailability enhancer, and a biodegradable polymer and which is designed to avoid rapid initial drug release (initial burst), contain a high concentration of the drug relative to particle size, have high bioavailability, and minimize patient discomfort and inflammatory reactions when administered to the human body, whereby the composition is useful in the prevention or treatment of diabetes, hypertension, hyperlipidemia, obesity, non-alcoholic steatohepatitis, or degenerative neurological diseases such as Alzheimer's and Parkinson's disease and in the preservation of beta-cell functions.

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Inventors:

LEE JUHWA (KR)
KIM HYEMIN (KR)
MOON SUNGWOONG (KR)
LEE JINWOO (KR)
NA YONGHA (KR)
JEONG HEON (KR)
LEE JUHAN (KR)
SEOL EUNYOUNG (KR)
LEE HEEYONG (KR)

Application Number:

PCT/KR2023/009535

Publication Date:

January 11, 2024

Filing Date:

July 05, 2023

Export Citation:

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Assignee:

G2GBIO INC (KR)

International Classes:

A61K9/16; A61K38/26; A61P1/16; A61P3/04; A61P3/10; A61P9/12; A61P25/28

Foreign References:

KR20220035361A	2022-03-22
KR102212717B1	2021-02-08
KR20210100986A	2021-08-18
KR101651101B1	2016-08-26
KR20160031308A	2016-03-22
KR20090116494A	2009-11-11

Other References:

GE YUXUAN, HU ZHENHUA, CHEN JILI, QIN YUJIE, WU FEI, JIN TUO: "Exenatide Microspheres for Monthly Controlled-Release Aided by Magnesium Hydroxide", PHARMACEUTICS, MDPI AG, CH, vol. 13, no. 6, CH , pages 816, XP093126522, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13060816

Attorney, Agent or Firm:

YOU ME PATENT AND LAW FIRM (KR)

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