SUSTAINED-RELEASE PHARMACEUTICAL FORMULATION OF FUSED TRICYCLIC Γ-AMINO ACID DERIVATIVE AND PREPARATION METHOD THEREFOR

Title:

SUSTAINED-RELEASE PHARMACEUTICAL FORMULATION OF FUSED TRICYCLIC Γ-AMINO ACID DERIVATIVE AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2022/017364

Kind Code:

A1

Abstract:

Disclosed are a sustained-release pharmaceutical formulation of a fused tricyclic γ-amino acid derivative and a preparation method therefor. The fused tricyclic γ-amino acid derivative is a compound represented by formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a eutectic crystal thereof.

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JP2007291124	AMINO ACIDS WITH AFFINITY FOR ALPHA 2 DELTA-PROTEIN

Inventors:

WANG QINGHAI (CN)
LI XIAOPING (CN)
REN DONG (CN)
WANG SHUNHONG (CN)

Application Number:

PCT/CN2021/107286

Publication Date:

January 27, 2022

Filing Date:

July 20, 2021

Export Citation:

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Assignee:

SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)

International Classes:

C07C229/28; A61K31/195; A61P25/04; A61P29/00

Domestic Patent References:

WO2020011257A1	2020-01-16
WO2018050046A1	2018-03-22
WO2018050046A1	2018-03-22
WO2020011258A1	2020-01-16

Foreign References:

CN111053749A	2020-04-24
CN101120929A	2008-02-13

Other References:

FELIX ET AL., J. NEUROSCIENCE, vol. 17, 1997, pages 6884 - 6891
KLUGBAUER ET AL., J. NEUROSCIENCE, vol. 19, 1999, pages 684 - 691
HOBOM, EUR. J. NEUROSCIENCE, vol. 12, 2000, pages 1217 - 1226
QIN ET AL., MOL. PHARMACOL, vol. 62, 2002, pages 485 - 496
ACTA NEUROL. SCAND, vol. 101, 2000, pages 359 - 371
AM J HEALTH SYST PHARM, vol. 64, no. 14, 2007, pages 1475 - 1482
See also references of EP 4183771A4

Attorney, Agent or Firm:

BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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