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Title:
SUSTAINED-RELEASE PREPARATION OF AQUEOUS DISPERSION TYPE AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/037660
Kind Code:
A1
Abstract:
The process comprises: a first step in which a monomer ingredient comprising at least one member selected between a (meth)acrylate monomer containing a photoinitiator group (ingredient (a1)) and a radical-polymerizable organic peroxide (ingredient (a2)) and further comprising a (meth)acrylate monomer and a polyfunctional (meth)acrylate monomer and optionally containing a hydrophilic monomer is copolymerized by emulsion polymerization in water in the presence of a functional substance, a surfactant, and a polymerization initiator to obtain an emulsion; and a second step in which a (meth)acrylate monomer and a polyfunctional (meth)acrylate monomer are added to the emulsion obtained in the first step to polymerize the monomers. Thus, a sustained-release preparation of the aqueous dispersion type is synthesized in which the functional substance is contained in an IPN.

Inventors:
TAMURA TORU (JP)
TASAKA TOMOHISA (JP)
NAKAMURA TETSUYA (JP)
SUGIURA MOTOYUKI (JP)
Application Number:
PCT/JP2000/008102
Publication Date:
May 31, 2001
Filing Date:
November 16, 2000
Export Citation:
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Assignee:
NOF CORP (JP)
TAMURA TORU (JP)
TASAKA TOMOHISA (JP)
NAKAMURA TETSUYA (JP)
SUGIURA MOTOYUKI (JP)
International Classes:
A01N25/04; A01N25/10; A01N35/02; A01N37/02; A01N43/20; A61K47/32; C08F220/18; (IPC1-7): A01N25/04; A01N25/10; A01N25/22; A61K9/10; C08F20/12; C08L33/04
Domestic Patent References:
WO1995030411A11995-11-16
WO1998000170A11998-01-08
Foreign References:
EP0347145A21989-12-20
EP0046136A21982-02-17
JPH0838865A1996-02-13
EP0816430A21998-01-07
JPH01315402A1989-12-20
JPS6272710A1987-04-03
JPS61181812A1986-08-14
Other References:
YAUNG J.F. ET AL.: "pH-sensitive hydrogels based on polyvinylpyrrolidone-polyacrylic acid(PVP-PAA) semi-interpenetrating networks)Semi-IPN): Swelling and controlled release", JOURNAL OF APPLIED POLYMER SCIENCE, vol. 69, no. 5, 1998, pages 921 - 930, XP002936549
MASAHIKO KAWASHIMA ET AL.: "Boujun no ondo izonsei seigyo wo mokuteki to shita suiso ketsugousei koubunshi IPN no bunshi sekkei", KOUBUNSHI GAKKAI YOKOUSHUU, vol. 41, no. 3, 1995, pages 763, XP002936550
See also references of EP 1230855A4
Attorney, Agent or Firm:
Goro, Kazuo (8th floor 22-4 Meieki 3-chome Nakamura-ku, Nagoya-shi Aichi, JP)
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