Title:
SYNTHESIS METHOD FOR LOXOPROFEN AND ANALOGUES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/108601
Kind Code:
A1
Abstract:
A synthesis method for loxoprofen and analogues thereof as shown in the following reaction formula, wherein compound (I) undergoes a reaction under the catalysis of a catalyst to generate compound (II). The method avoids the use of a large amount of an acid solution and can be performed under solvent-free conditions, and therefore the method is more environmentally friendly. The used catalyst can be recycled and reused, the recovery rate of the catalyst reaches 98%, and the discharge of the three wastes and environmental pollution are greatly reduced.
Inventors:
MEI YIJIANG (CN)
LI JIEPING (CN)
LI YONGGANG (CN)
YU SHUAI (CN)
HU KAI (CN)
WANG CHANGFA (CN)
WANG LUFENG (CN)
LI JIEPING (CN)
LI YONGGANG (CN)
YU SHUAI (CN)
HU KAI (CN)
WANG CHANGFA (CN)
WANG LUFENG (CN)
Application Number:
PCT/CN2021/139085
Publication Date:
June 22, 2023
Filing Date:
December 17, 2021
Export Citation:
Assignee:
ZHEJIANG JIUZHOU PHARM CO LTD (CN)
International Classes:
C07C67/32; C07C69/738; C07C253/30; C07C255/40
Domestic Patent References:
| WO2015075981A1 | 2015-05-28 | |||
| WO1997024308A1 | 1997-07-10 |
Foreign References:
| CN108440274A | 2018-08-24 | |||
| CN104684881A | 2015-06-03 | |||
| CN101412670A | 2009-04-22 | |||
| CN104326903A | 2015-02-04 | |||
| CN104710309A | 2015-06-17 |
Attorney, Agent or Firm:
ZHEJIANG KG IP LAW FIRM (CN)
Download PDF: