Title:
SYNTHESIS METHOD FOR PENTOXIFYLLINE
Document Type and Number:
WIPO Patent Application WO/2022/247065
Kind Code:
A1
Abstract:
The present invention relates to the field of drug synthesis. Disclosed is a synthesis method for pentoxifylline. The synthesis method performs condensation and ring closure by means of 4-(nitrogen methyl chloride)-1-methylimidazole-5-acyl chloride and amino-5-hexanone, thereby synthesizing a target product, i.e., pentoxifylline, using only a one-step reaction. The synthesis method for pentoxifylline provided by the present invention not only has a simple synthesis process, but also can recycle a by-product produced during a reaction process for further synthesis of pentoxifylline. The present invention is suitable for the synthesis of pentoxifylline, and the synthesized pentoxifylline is used for preparing pentoxifylline for injection.
Inventors:
TANG XIONGZHAO (CN)
FU YONGHONG (CN)
LIN FANGYU (CN)
XIAO HANWEN (CN)
LIN XIAOXUE (CN)
FU YONGHONG (CN)
LIN FANGYU (CN)
XIAO HANWEN (CN)
LIN XIAOXUE (CN)
Application Number:
PCT/CN2021/118260
Publication Date:
December 01, 2022
Filing Date:
September 14, 2021
Export Citation:
Assignee:
CHINA MEHECO KANGLI PHARMA CO LTD (CN)
International Classes:
C07D473/10
Foreign References:
| CN113214259A | 2021-08-06 | |||
| JPS53149997A | 1978-12-27 | |||
| JPS5412397A | 1979-01-30 | |||
| CN101648951A | 2010-02-17 |
Attorney, Agent or Firm:
BEIJING HC-IP AGENCY CO., LTD. (GENERALPARTNERSHIP) (CN)
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