SYNTHESIS OF MIDODRINE HCI FROM A NOVEL INTERMEDIATE 1-(2',5'-DIMETHOXYPHENYL)-2-AZIDOETHANONE

WIPO Patent Application WO2001079154

A3

Midodrine hydrochloride, +/- 1-(2',5'-dimethoxyphenyl)-2-glycineamido-ethanol-(1)- HCI, is prepared from a novel intermediate, 1-(2',5'-dimethoxyphenyl)-2-azidoethanone.

WO/2023/277587	METHOD FOR PREPARING N-ACYL DERIVATIVE, COMPOSITION, AND PHARMACEUTICAL OR AGRICULTURAL PRODUCT CONTAINING SAME
WO/2003/032971	5’−ACYLAMINO−1,1’−BIPHENYL−4−CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS

RAY ANUP KUMAR
PATEL HIREN KUMAR V
PATEL MAHENDRA R

PCT/EP2001/004348

March 21, 2002

April 17, 2001

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NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)

C07C231/14; C07C237/08; C07C247/10; (IPC1-7): C07C231/14; C07C237/08; C07C247/10

AT241435B	1965-07-26
FR2300757A1	1976-09-10

DATABASE WPI Section Ch Week 199601, Derwent World Patents Index; Class B05, AN 1996-006927, XP002170448
BORG S ET AL: "SYNTHESIS OF 1,2,4-OXADIAZOLE-, 1,3,4-OXADIAZOLE-, AND 1,2,4-TRIAZOLE-DERIVED DIPEPTIDOMIMETICS", JOURNAL OF ORGANIC CHEMISTRY,AMERICAN CHEMICAL SOCIETY. EASTON,US, vol. 60, no. 10, 19 May 1995 (1995-05-19), pages 3112 - 3120, XP000973994, ISSN: 0022-3263
JIAWANG ZHU ET AL: "Incorporation of chromium aminocarbene complex-derived", JOURNAL OF ORGANIC CHEMISTRY,AMERICAN CHEMICAL SOCIETY. EASTON,US, vol. 60, no. 18, 1995, pages 5831 - 5837, XP002155726, ISSN: 0022-3263
BARDEN T C ET AL: "GLYCYLCYCLINES 3. 9-AMINODOXYCYCLINECARBOXAMIDES", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 37, 30 September 1994 (1994-09-30), pages 3205 - 3211, XP000608350, ISSN: 0022-2623

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