SYNTHESIS OF NITROALCOHOL DIASTEREOMERS

WIPO Patent Application WO2000050378

A3

The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula (I): In Structural Formula (I), R is an amine protecting group, and R<1> is an amino acid side-chain, a protected amino acid side-chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl group. The method involves a contacting a 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. The 1-nitro-3-substituted-3-amino-2-propanol diastereomers are then separated by simulated moving bed chromatography to obtain one or more 1-nitro-3-substituted-3-amino-2-propanol diastereomer.

GABRIEL RICHARD L (US)
MOUSSA ADEL M (US)
FITZHENRY SHARON (US)
LIU CHANGHUA (US)
SWANSON DAVID A (US)
LA BRITANNY (US)
ZAHR SALAH (US)

PCT/US2000/004576

April 05, 2001

February 23, 2000

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PHARM ECO LAB INC (US)
GABRIEL RICHARD L (US)
MOUSSA ADEL M (US)
FITZHENRY SHARON (US)
LIU CHANGHUA (US)
SWANSON DAVID A (US)
BRITANNY (US)
ZAHR SALAH (US)

B01J20/286; B01D15/00; B01D15/08; B01J20/285; B01J20/291; C07B57/00; C07C213/00; C07C227/02; C07C227/34; C07C229/34; C07C269/06; C07C271/16; G01N30/26; G01N30/46; G01N30/88; B01D15/18; C07C215/28; (IPC1-7): C07C213/00; C07C215/28

WO1996001788A2	1996-01-25
WO1997045185A1	1997-12-04

PATENT ABSTRACTS OF JAPAN vol. 014, no. 236 (C - 0720) 18 May 1990 (1990-05-18)

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