Title:
SYNTHESIS OF OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO1998051698
Kind Code:
A8
Abstract:
A method of preparing an immobilized oligonucleotide having a free 3'-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3'-end and having a free 5'-end; ii) binding said oligonucleotide in a second position remote from the 3'-end to the solid support; and iii) selectively releasing the 3'-end of the oligonucleotide from the solid support to obtain the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3'-end.
Inventors:
KWIATKOWSKI MAREK (SE)
LANDEGREN ULF (SE)
NILSSON MATS (SE)
LANDEGREN ULF (SE)
NILSSON MATS (SE)
Application Number:
PCT/SE1998/000893
Publication Date:
June 10, 1999
Filing Date:
May 14, 1998
Export Citation:
Assignee:
KWIATKOWSKI MAREK (SE)
LANDEGREN ULF (SE)
NILSSON MATS (SE)
LANDEGREN ULF (SE)
NILSSON MATS (SE)
International Classes:
C07H21/00; C12Q1/6834; C12Q1/68; (IPC1-7): C07H21/00; C07H21/02; C07H21/04
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