Title:
SYNTHESIS AND OPTICAL RESOLUTION OF THE TAXOL SIDE CHAIN AND RELATED COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1993/010076
Kind Code:
A1
Abstract:
This invention relates to a method for the production of a substantially optically pure taxane side chain comprising the steps of synthesizing a racemic mixture of enantiomers of the taxane side chain that is capable of exhibiting conglomerate behavior and resolving the substantially optically pure enantiomers by direct crystallization methods. This invention also relates to the semisynthesis of taxanes such as taxol through coupling the substantially optically pure taxane side chain to a taxane ring nucleus.
Inventors:
PETERSON JOHN R (US)
ZJAWIONY JORDAN K (US)
ROGERS ROBIN D (US)
ZJAWIONY JORDAN K (US)
ROGERS ROBIN D (US)
Application Number:
PCT/US1992/009911
Publication Date:
May 27, 1993
Filing Date:
November 19, 1992
Export Citation:
Assignee:
UNIV MISSISSIPPI (US)
International Classes:
C07C69/732; C07C231/20; C07D305/14; (IPC1-7): C07C69/675; C07C231/20; C07C233/87; C07D305/14
Domestic Patent References:
| WO1991013066A2 | 1991-09-05 |
Other References:
JOURNAL OF ORGANIC CHEMISTRY vol. 51, no. 1, 10 January 1986, EASTON US pages 46 - 50 A. E. GREENE 'An Efficient, Enantioselective Synthesis of the Taxol Side Chain' cited in the application
JOURNAL OF ORGANIC CHEMISTRY vol. 28, no. 7, June 1963, EASTON US pages 2009 - 2012 C. C. TUNG, A. J. SPEZIALE 'Epoxide Studies. The Ring Opening of cis- and trans-N,N-Diethylphenylglycidamide' cited in the application
JOURNAL OF ORGANIC CHEMISTRY vol. 55, no. 6, 16 March 1990, EASTON US pages 1957 - 1959 A. E. GREENE 'An Improved Synthesis of the Taxol Side Chain and of RP 56976' cited in the application
JOURNAL OF ORGANIC CHEMISTRY vol. 28, no. 7, June 1963, EASTON US pages 2009 - 2012 C. C. TUNG, A. J. SPEZIALE 'Epoxide Studies. The Ring Opening of cis- and trans-N,N-Diethylphenylglycidamide' cited in the application
JOURNAL OF ORGANIC CHEMISTRY vol. 55, no. 6, 16 March 1990, EASTON US pages 1957 - 1959 A. E. GREENE 'An Improved Synthesis of the Taxol Side Chain and of RP 56976' cited in the application
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