Title:
SYNTHESIS OF SELENIUM-DERIVATIZED NUCLEOSIDES, NUCLEOTIDES, PHOSPHORAMIDITES, TRIPHOSPHATES AND NUCLEIC ACIDS
Document Type and Number:
WIPO Patent Application WO2002077002
Kind Code:
A3
Abstract:
The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonulcleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
Inventors:
HUANG ZHEN (US)
Application Number:
PCT/US2002/008771
Publication Date:
December 19, 2002
Filing Date:
March 22, 2002
Export Citation:
Assignee:
UNIV CITY (US)
HUANG ZHEN (US)
HUANG ZHEN (US)
International Classes:
C07H5/08; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00; (IPC1-7): C07D239/28; C07D421/04; A61K31/095
Domestic Patent References:
| WO1998049179A2 | 1998-11-05 |
Foreign References:
| US5883237A | 1999-03-16 |
Other References:
DU ET AL.: "Internal derivation of oligonucleotides with selenium for X-ray crystallography using MAD", J. AM. CHEM. SOC., vol. 124, no. 1, 2002, pages 24 - 25, XP002954874
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