Description of the Related Art Terfenadine (Formula T) is a non-sedating antihistamine sold in the U.S. under the designation "Seldane" (Hoechst Marion Roussel).

Certain derivatives of terfenadine are also known and disclosed as active antihistamines, e.g., in U.S.

Pat. No. 4,254,129 (Carr et al.) The primary active metabolite of terfenadine is a compound known as terfenadine carboxylate or fexofenadine (Formula B), which is among the terfenadine derivatives disclosed in U.S. Pat. No. 4,254,129. The hydrochloride salt of terfenadine carboxylate is sold in the U.S. under the designation "Allegra" (Hoechst Marion Roussel).

Several synthetic methods for preparing terfenadine and derivatives thereof have been disclosed. For example, Carr et al. disclose a method involving acylation of a compound of Formula C and further elaboration to provide terfenadine carboxylate.

The acylation step in this method, however, is said in International Patent Application No. WO 95/00482 (D'Ambra) to provide a mixture of regioisomers that includes the 3-substituted product in addition to the desired 4-substituted product. D'Ambra provides substantially pure regioisomers, e.g., through fractional crystallization of the acylation product.

Regiochemically pure 4-substituted product for use in preparing terfenadine and derivatives can also be produced using a metal-mediated coupling approach, as described in J. Org. Chem. 1994, 59, 2620 (Kawai et al.), where 3-butyn-1-ol is coupled to methyl 2-(4- halophenyl)-2,2-dimethylacetate.

The process of the invention described below exhibits at least two major advantages over the processes of the art: (1) It is regiospecific; the manipulative complications that arise from the presence of multiple isomers are avoided. (2) The yield from aldehyde to final product is very much higher than known processes - 59% overall.

Summary of the Invention This invention provides processes for preparing compounds of Formula I wherein Rl is methyl, protected hydroxymethyl or protected carboxyl and -OR2 is protected hydroxyl or hydroxyl.

In one aspect, the invention relates to a process comprising subjecting a compound of Formula IVa or a tautomer thereof, to reductive amination with a,-diphenyl-4-piperidinemethanol and a reducing agent to provide a compound of Formula I

The compound of formula IVa may be prepared by treating a compound of Formula IV wherein A is a precursor of a formylmethyl group, with a reagent capable of converting the precursor of a formylmethyl group to a formylmethyl group. The compound of formula IV may be prepared by contacting a compound of Formula II with a compound of Formula III (MX) [CH2-A] III wherein MX is a cationic metal-containing moiety and n is the net valence of MX. This process provides a compound of the formula E in which the hydroxy group may be protected, if desired, to provide the compound of Formula IV. In a preferred embodiment, MX is MgBr and A is chosen from the group consisting of 2,2-di(lower- alkoxy)ethyl; (1,3-dioxolan-2-yl)methyl; (1,3-dioxan- 2-yl)methyl; (1,3-dioxetan-2-yl)methyl; and (1,3- benzodioxolan-2-yl)methyl.

In another aspect, the invention relates to a process comprising contacting a compound of formula VI with a reducing agent to provide compounds of formula The compound of formula VI may be prepared by contacting a compound of Formula IVc

with a,-diphenyl-4-piperidinemethanol and a reducing agent.

In either of the foregoing processes, the reducing agent may be a borohydride or aluminum hydride. When Rl is protected hydroxymethyl or protected carboxyl and R2 is hydrogen, an additional step of deprotecting Rl to provides a compound of Formula B or D When Rl is protected hydroxymethyl or protected carboxyl and R2 is a protecting group for hydroxyl, two additional steps of deprotecting Rl and R2 provide the compounds of Formula B and D. When the protecting groups are appropriate, these two steps may be combined into a single operation.

When Rl is methyl and R2 is a protecting group for hydroxyl, an additional step of deprotecting R2 provides a compound of Formula T In some embodiments Rl may be chosen from the group consisting of wherein D represents the residue of a 5- or 6- membered, saturated or aromatic ring. R2 may be chosen from hydrogen, trialkylsilyl, benzyl, tetrahydropyran-2-yl, lower-alkylcarbonyl, arylcarbonyl and arylmethyl. The aryl group is preferably phenyl, optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo. R3 may be chosen from: (1) alkoxy, wherein the alkoxy group contains from one to about 8

carbon atoms; (2) alkenyloxy, wherein the alkenyloxy group contains from one to about 4 carbon atoms; (3) arylmethoxy, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo; and (4) -NR6R7, in which R6 and R7 are hydrogen, alkyl of 1 to 8 carbons or benzyl.

In compounds in which Rl is -CH2OR4, R4 may be trialkylsilyl, Li+, benzyl, tetrahydropyran-2-yl, lower-alkylcarbonyl, arylcarbonyl and arylmethyl, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo. In compounds in which Rl is -C(oR5) R5 R5 is alkyl of 1 to 6 carbons.

When Rl and R4 are the same, deprotection of -OR and -CH2OR4 may be carried out in a single step.

The invention, in a particular embodiment, provides a complete process for the production of terfenadine carboxylate comprising the sequential steps of: (a) reacting a compound of formula IIa with from 1 to 1.5 equivalents of a Grignard reagent of formula IIIa in an ethereal solvent to provide an intermediate of formula IVe (The intermediate may be described by formula IV in which R' is a protected carboxyl and A is precursor of a formyl methyl group) (b) deprotecting the intermediate by treating with aqueous acid (optionally a sulfonic acid ion exchange resin in the presence of water) to provide a mixture of aldehyde IVf and corresponding tautomeric lactol IVb: (c) reductively aminating the aldehyde/lactol tautomeric mixture by treating with about one equivalent of a, a-diphenyl-4-piperidinemethanol and an excess of a borohydride reducing agent in a solvent to provide a compound of formula I in which R

is COOEt and R2 is hydrogen; (d) deprotecting by reacting with an excess of aqueous base, preferably an alkali metal hydroxide; and (e) recovering terfenadine carboxylate by acidifying and filtering.

In another aspect, the invention relates to compounds of Formula IVd in which: (1) Rl is chosen from the group consisting of wherein D represents the residue of a 5- or 6- membered, saturated or aromatic ring; (2) R2 is chosen from hydrogen, trialkylsilyl, benzyl, tetrahydropyran-2 -yl, lower-alkylcarbonyl, arylcarbonyl and arylmethyl, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo; (3) R3 is chosen from alkoxy, wherein the alkoxy group contains from one to about 8 carbon atoms; alkenyloxy, wherein the alkenyloxy group

contains from one to about 4 carbon atoms; arylmethoxy, wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo; (4) -NR6R7, wherein R4, R5, R6 and R7 are as defined above, and (5) Al is chosen from the group consisting of formylmethyl, vinyl, ethynyl, vinylmethyl, cyanomethyl, 2,2-di(lower-alkoxy)ethyl; (1,3-dioxolan-2-yl)methyl; (1,3-dioxan-2-yl)methyl; (1,3-dioxetan-2-yl)methyl; and (1,3-benzodioxolan-2- yl)methyl.

In another aspect, the invention relates to compounds of Formula VI and IVg and IX

wherein Rl to R7 are as defined above for IVd and R8 is OHC- or The compounds are useful as intermediates in the synthesis of antihistamines.

Detailed Description of the Invention The term "lower" when used herein in connection with "alkyl" or "alkoxy" designates a straight or branched chain containing one to about four carbon atoms. The configuration of any carbon-carbon double bond appearing herein is selected for convenience only and is not intended to designate a particular configuration; thus a carbon-carbon double bond depicted arbitrarily herein as trans may be cis, trans, or a mixture of the two in any proportion.

Terminology related to "protecting", "deprotecting" and "protected" functionalities occurs throughout this application. Such terminology is well understood by persons of skill in the art and is used in the context of processes which involve sequential treatment with a series of reagents. In that context, a protecting group refers to a group which is used to mask a functionality during a process step in which it would otherwise react, but in which reaction is undesirable. The protecting

group prevents reaction at that step, but may be subsequently removed to expose the original functionality. The removal or "deprotection" occurs after the completion of the reaction or reactions in which the functionality would interfere. Thus, when a sequence of reagents is specified, as it is in the processes of the invention, the person of ordinary skill can readily envision those groups that would be suitable as "protecting groups".

In the case of the present invention, the functionalities that must be protected are carboxylic acids and alcohols. Suitable groups for that purpose are discussed in standard textbooks in the field of chemistry, such as Protective Groups in Organic Synthesis by T.W.Greene [John Wiley & Sons, New York, 1991], which is incorporated herein by reference.

Particular attention is drawn to the chapters entitled "Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols" (pages 10-86) and "Protection for the Carboxyl Group" (pages 152-end).

A generalized synthetic scheme showing the various interrelated processes of the invention is presented in Scheme A: Scheme A X R R C H lat IOfl or /bromination Iky I at Ion ri ssidstlon t 0 0 ½ Br < > s , \carboxylation / II \ \ / / \ Grignard [,Seo] HOOT/ OH E esterif Ication Grignard | AJ |deprotection deprotection ,deprotection 5 CHC ' R1 0 HO

Scheme A (continued) OHC s R1 0 HO NH reductive H 0 r eductive amp nation am I nation Ph and Ph reduction N 1 HO Hz OR Ph Ph The process of the invention can be carried out using a compound of the general Formula II wherein R1 is substantially inert to the conditions used in the step that involves nucleophilic addition of a compound of Formula III to the formyl group of the compound of Formula II. Suitable R1 groups include those that provide esters (e.g., ethenyloxycarbonyl, alkoxycarbonyl wherein the alkoxy group contains from one to about 8 carbon atoms, and arylmethoxycarbonyl wherein the aryl group is phenyl optionally substituted with from one to three substituents each independently selected from the group consisting of lower alkyl, lower alkoxy, and halo), amides (e.g., aminocarbonyl, mono- or dialkylaminocarbonyl wherein each alkyl group is independently lower alkyl,

benzylaminocarbonyl, and the like ), oxazolines (e.g., 2-(1-oxa-3-azacyclopent-2-enyl, optionally annelated with propenyl, butenyl, or benzo), nitriles (cyano), and orthoesters (e.g., trialkoxymethyl wherein each alkoxy group independently contains from 1 to about 8 carbon atoms); protected hydroxymethyl (e.g., trialkylsilyloxymethyl wherein each alkyl group independently contains one to about 6 carbon atoms, -CH2OThi, benzyloxymethyl, tetrahydropyranyl-2- oxymethyl, and the like), and methyl.

Compounds of Formula II can be prepared in several steps from commercially available starting materials (e.g., p-tolylacetic acid or its esters, alkyl phenylacetates, p-bromophenylacetic acid and its esters, and the like) using methods well known to those skilled in the art. The compound of Formula II in which R1 is an ethyl ester is known in the art [See Maillard et al. Chim. Ther. 8, 487-494 (1973).] It may be prepared as described below from ethyl 2-p- tolyl-2-methylpropionate by bromination and treatment with hexamethylenetetramine or from ethyl 2-phenyl-2- methylpropionate by treatment with dichloromethyl- methylether and TiCl4. The starting material for the TiCl4 alkylation is cheaper than for the bromination/oxidation, but the alkylation is not regiospecific; however the para-aldehyde can be obtained readily in one crystallization of the bisulfite addition product.

Compounds of Formula II may also be prepared from the appropriately functionalized iodo- or bromoaryl compound by carbonylation in the presence of tin hydride and palladium according to the procedure of Baillargeon and Stille [J. Am. Chem.

Soc. 105, 7175-7176 (1983) and J. Am. Chem. Soc. 108, 452-461 (1986)], which are incorporated herein by reference.

The addition of three carbons to the aldehyde involves a compound of Formula III, (MX)[CH2-A] The moiety A in a compound of Formula III can be any moiety that can be converted to a formylmethyl group.

Suitable groups A include: vinyl, which can be converted to formylmethyl by hydroboration/oxidation; vinylmethyl or (substituted-vinyl)methyl, which can be converted to formylmethyl by oxidation with ozone, ruthenium tetroxide/sodium periodate, permanganate, and the like; cyanomethyl, which can be converted to formylmethyl by reduction with diisobutylaluminum hydride; and acetal-containing moieties such as 2,2- (dialkoxy)ethyl. Particularly suitable alkoxy groups include dimethoxyl, diethoxyl and cyclic acetals such as (1,3-dioxacyclopent-2-yl)methyl, (1,3- dioxacyclohex-2-yl)methyl; (1,3-dioxacyclobut-2- yl)methyl, and (1,3-dioxa(benzo)cyclopent-2- yl)methyl, all of which can be converted to formylmethyl by way of acid-catalyzed hydrolysis of the acetal group. As shown below, the acetal may be hydrolyzed with mineral acid or with a sulfonic acid ion exchange resin, such as Amberlyst or Dowex SO, in the acid form.

Suitable groups for use as the moiety MX in a compound of Formula III include Li +, MgX+ or ZnX+ wherein X is iodo, bromo, or chloro, CeCl2+and CuLi++.

The MX group and the protected formylmethyl group of a compound of Formula III are readily selected by those skilled in the art to be compatible. For example, groups that render the compound strongly

nucleophilic, such as MgBr, are not preferred when A is an electrophile such as cyanomethyl; however, MX may be, e.g., CuLi++when A is cyanomethyl. Compounds of Formula III can be prepared using methods well known to those skilled in the art, e.g., from the corresponding compound having bromo in place of MX.

In the step in which a compound of Formula II is contacted with a compound of Formula III, the compound of Formula III is preferably prepared in a suitable inert solvent (e.g., an ethereal solvent such as tetrahydrofuran, diethyl ether, diisopropyl ether, diisobutyl ether, or dimethoxyethane) and added with stirring to a solution of a compound of Formula II in an inert solvent. Preferably the temperature of the reaction is controlled in order to avoid undesired side reactions, and the rate of addition is controlled in order to maintain the controlled temperature throughout the addition.

This step may optionally involve an additional step of protecting the hydroxy group that results from the nucleophilic addition to the aldehyde.

Suitable protected hydroxy groups can be readily selected and incorporated by those skilled in the art, and include esters (e.g., -OR2 wherein R2is lower alkylcarbonyl, benzoyl, substituted benzoyl wherein the substituent is lower alkyl, lower alkoxy, or halo) or ethers (e.g., -OR2 wherein R2 is benzyl or substituted benzyl wherein the substituent is lower alkyl, lower alkoxy, or halo).

Two alternative pathways are shown in parallel from II to product in Scheme A: the right branch, described above, proceeds through intermediates in

which the oxygen adjacent the benzene ring is in the alcohol oxidation state; the left branch proceeds through intermediates in which the oxygen adjacent the benzene ring is in the ketone oxidation state.

According to this second alternative, one may prepare the keto-aldehyde VIII corresponding to the hydroxy-aldehyde IVf.

The aldehyde may then be selectively, reductively aminated with a,-diphenyl-4-piperidinemethanol and the ketone may be reduced subsequently or concomitantly.

Although the keto-aldehyde VIII may be prepared by oxidation of the alcohol IVe and subsequent deprotection of the acetal or protected formyl group, it may also be prepared directly from the carboxylic acid corresponding to IIa, as shown in Scheme A, by Grignard addition to an acid derivative, such as an ester, followed by deprotection of the formyl equivalent. We have observed that the aldehyde IIa oxidizes to the carboxylic acid in air, making carboxylic acid derivatives readily accessible.

Alternatively, the carboxylic acid or, an ester thereof, may be synthesized from the corresponding iodo- or bromoaryl compound by carbonylation in the presence of a palladium catalyst; an example of this procedure is given by Baldwin et al. [Tetrahedron 42, 3943-3956 (1986) at page 3951]. The carboxylic acid

can be derivatized by the procedure of Weinreb [Tetrahedron Letters 22, 3815-3818 (1981)] with methoxymethylhydroxylamine or by the procedure of Rappoport [J. Ors. Chem. 61, 6071-6074 (1996)] with methanesulfonic acid and dihydrofuran. The foregoing references are incorporated herein by reference. In either case, the resulting ester can be reacted with the Grignard IIIa to provide the aldehyde-protected keto-aldehyde.

In the next step in the sequence, the protected formylmethyl group is deprotected to afford a compound of general Formula IVa, which, when R2 is hydrogen, exists predominantly as the lactol tautomer IVb rather than the hydroxyaldehyde IVf. In the "left branch' synthesis via the ketone, the deprotected keto-aldehyde obviously does not cyclize.

Suitable methods of deprotection include those discussed above in connection with compounds of Formula III. The hydroxyaldehyde and the lactol IVb are both suitable for use in reductive amination.

Under most conditions the aldehyde/lactol equilibrium lies far to the right, and the lactol predominates by as much as 98:2. Similarly, the ketoaldehyde VIII may be reductively aminated (at the aldehyde) and reduced (at the ketone) simultaneously, or at least in the same pot.

The reductive amination process involves a first step of contacting the aldehyde or lactol with ,- diphenyl-4-piperidinomethanol (Formula V above).

The reaction is preferably carried out by adding an excess of the compound of Formula V to a solution of IVf/IVb in a hydroxylic solvent (e.g., methanol, ethanol, 2-propanol) to afford an addition product

that comprises an enamine of formula VI or a mixture of the enamine VI, the iminium salt VIa and the a- hydroxyamine VIb The enamine VI may be in the cis or trans configuration or may be a mixture of the two.

The addition product can be reduced to provide a compound of Formula I. The reduction can be carried out using conventional methodology (e.g., sodium borohydride, sodium cyanoborohydride, diisobutylaluminum hydride, lithium aluminum hydride, sodium acetoxyborohydride, or catalytic hydrogenation

using platinum, palladium, or nickel as catalyst).

It is preferred that the reduction be carried out without isolation of the intermediate addition product.

In another embodiment of this invention, a compound of Formula IVb is oxidized to provide the corresponding lactone of Formula IVc The oxidation can be carried out using conventional oxidizing agents such as pyridinium dichromate, pyridinium chlorochromate, or DMSO/triethylamine.

The lactone of Formula IVc can be converted to a compound of Formula VI by reduction with reducing agents known to convert esters to aldehydes (e.g., diisobutylaluminum hydride) followed by addition of a,-diphenyl-4-piperidinomethanol and appropriate reduction of the product as described above.

In a preferred embodiment of the invention R1 is a protected carboxy group. For example, R1 can constitute functionality that provides esters (e.g., ethenyloxycarbonyl, allyloxycarbonyl, methoxycarbonyl, ethoxycarbonyl and benzyloxycarbonyl or substituted benzyloxycarbonyl), amides (e.g., aminocarbonyl, mono- or dialkylaminocarbonyl wherein each alkyl group is independently lower alkyl, benzylaminocarbonyl, and the like), oxazolines (e.g.

1-oxa-3-azacyclopent-2-enyl, optionally annelated with propenyl, butenyl, or benzo), nitriles (cyan) and orthoesters (e.g.,trialkoxymethyl wherein each

alkoxy group independently contains from 1 to about 8 carbon atoms). These protected carboxy groups can be readily deprotected to provide a carboxy group, thus affording the antihistamine terfenadine carboxylate (Formula B).

In yet another preferred embodiment of the invention R1 of Formula I is a protected hydroxymethyl group. For example, R1 can constitute trialkylsilyloxymethyl wherein each alkyl group independently contains one to about 6 carbon atoms, - CH2OLi, benzyloxymethyl, tetrahydropyranyl-2 - oxymethyl, and the like. These protected hydroxymethyl groups can be readily deprotected to provide a hydroxymethyl group, thus affording the antihistaminic compound of Formula D: The invention is illustrated by the following Examples.

Examples Ethyl 2-p-Tolyl-2-Methyl Propionate: Sodium hydride ( 17.6 g, 60% by wt, 0.43 mol) was washed with hexane (2 x 60 mL) to remove mineral oil and was suspended in anhydrous THF (200 mL) under nitrogen.

A solution of ethyl p-tolyl acetate (17.8 g, 0.10 mol) in THF (40 mL) was slowly added to the above suspension in 20 min and the resulting suspension was

stirred at 22 OC for 30 min. lodomethane (52.4 g, 0.37 mol) was added dropwise to the above suspension over 30 min at 22 OC (the reaction is exothermic and the reaction flask should be equipped with a condenser and cooled with a water bath). After 3 h stirring, the reaction mixture was quenched with florisil (12 g), and stirred for 30 min. The reaction mixture was filtered through a celite pad.

The reaction flask was rinsed with THF (50 mL) and used to wash the celite pad. The filtrate was concentrated to give a residue, which was partitioned between MTBE (200 mL) and water (150 mL). The organic layer was washed with brine (40 mL), dried over Na2SO4 (20 g) and concentrated to give an oil. The crude product was used for the next step without purification. 1H NMR (CDCl3) d 1.10-1.150 (t, J = 7.5 Hz, 3H), 1.62 ( s, 6 H), 2.38 (s, 3H), 4.11-4.20 (q, J =7.5 Hz, 2H), 7.12-7.30 (m, 4H).

The reaction was repeated on a larger scale as follows: Sodium hydride (43g, 95% by wt, 1.68 mol) was washed and suspended in anhydrous THF (1200 mL) under nitrogen while cooled with ice-water bath. A solution of ethyl p-tolyl acetate (120g, 0.67 mol) in THF (40 mL) was added to the above suspension slowly over 20 min, and the resulting suspension was stirred at 220 for 30 min. Iodomethane (23g, 1.68 mol) was added dropwise to the above suspension over 1.5 h at 220C (the reaction is exothermic and the reaction flask should be equipped with a condenser and cooled with a water bath). After the addition, the reaction mixture was heated at reflux for 2 h, and was quenched with water (1.5 L), very slowly to destroy the excess NaH at the beginning, while cooling with

an ice-water bath, then extracted with hexane (4 x 400 mL). The extracts were combined and washed with water, and brine, then dried over Na2SO4 (20g) and concentrated to give an oil (134g, 98% yield). The crude product was used in the next step without purification.

Ethyl 2-(4-Bromomethylphenyl)-2-Methyl Propionate: To a solution of ethyl 2-p-tolyl-2- methyl propionate (22 g, 106 mmol) in carbon tetrachloride (200 mL) NBS (22.8 g, 128 mmol) and benzoyl peroxide (0.5 g) was added at 22 OC. The reaction mixture was heated under reflux for 14 h.

The reaction mixture was cooled to 22 OC and filtered, the filtrate was concentrated to give an oily residue, which was passed through a short column of silica gel to remove the additional succinimide using EtOAc/hexane (1:9) to give an oil (31 g). The material was used for next the reaction without further purification. 1H NMR (CDC13) d 1.19-1.40 (t, J = 7.2 Hz, 3H), 1.59 (s, 6H), 4.08-4.18 (q, J = 7.2, 2H), 4.50 (s, 2H), 7.30 -7.38 (m, 4H).

Ethyl 2-(4-Formylphenyl)-2-Methylpropionate (formula II; R1 = COOEt): Hexamethylenetetramine (3.5 g) was dissolved in chloroform (50 mL) and followed by addition of ethyl 2-(4-bromethylphenyl)-2-methyl propionate (5.7 g) in chloroform (30 mL). The reaction mixture was stirred at 22 OC for 30 min and heated at reflux for 14 h, and concentrated to give a solid residue, without purification, the solid residue was suspended in water (100 mL) and heated at reflux for 15 h. The reaction mixture was then cooled to rt, extracted with EtOAc (30 mL), the organic phase was concentrated to give a crude oil,

which was purified by flash chromatography (EtOAc/hexane 1:9) to give 1.57 g (55%) analytically pure product. 'H NMR (CDCl3) d 1.12-1.17 (t, J = 7.2 Hz, 3H), 1.57 (s, 6H), 4.06-4.13 (q, J = 7.2 Hz, 2 H), 7.46-7.49 (d, J =8.7 Hz, 2H), 7.80-7.83 (d, J = 8.7 Hz, 2H), 9.96 (s, 1H).

Ethyl 2-(4-Formylphenyl)-2-Methylpropionate (formula II; R1 = COOEt) (alternate synthesis): Ethyl 2-phenyl-2-methylpropionate (10 g) was dissolved in 50 mL of dichloromethane and cooled to 50C. Titanium tetrachloride (10.5 mL) and 1,1-dichloromethyl methyl ether (7.5 mL) were added and the mixture was stirred at room temperature for 60 hours. The resulting dark solution was diluted with 50 mL of dichloromethane and washed twice with 50 mL of water. The organic solution was concentrated to give an oil which was treated with 30 mL of saturated aqueous sodium bisulfite solution for 12 hours. The precipitate was collected by filtration, washed with hexane, suspended in ethyl acetate and treated with excess potassium carbonate. The organic phase was separated, dried with sodium sulfate and stripped to provide 2 g of product.

Ethyl 2-[3-(1,3-Dioxolan-2-yl)-1-Hydroxy- Propylphenyl]-2-Methylpropionate: The Grignard reagent was prepared by addition of 2-(2-bromoethyl)- 1,3-dioxolane (4.32 g, 24 mmol) in THF (60 mL) to magnesium powder (0.62 g) over 10 min while keeping the reaction temperature below 50 OC by cooling with a water bath (10-20 OC). The reaction mixture was stirred for an additional 1 h. The Grignard reagent was then added to a solution of ethyl 2-(4- formylphenyl)-2-methylpropionate (4.4 g, 20 mmol) in

THF (20 mL) at - 78 OC via syringe over 5 min. The reaction mixture was then warmed to 22 OC over 25 min and stirred for 10 min at that temperature. The reaction mixture was poured into water (60 mL), followed by extraction with EtOAc (2 x 100 mL). The extracts were combined and washed with water (30 mL), dried over Na2SO4, and evaporated. The crude product can be used for the next step without purification.

It was purified by chromatography (EtOAc/Hexane 4:6) to give ethyl 2-[3-(1,3-dioxolan-2-yl)-1-hydroxy- propylphenyl]-2-methylpropinate (4.8 g, 75% yield).

H NMR (CDCl3) d 1.15-1.19 (t, J = 7.1 Hz, 3H), 1.55 (s, 6H), 1.65-1.90 (m, 4H), 2.92 (broad s, 1H) , 3.75- 3.88 (m, 2H), 3.90-3.97 (m, 2H), 4.06-4.13 (q, J = 7.0 Hz, 2H), 4.65-4.69 (m, lH) , 4.86-4.89 (m, 1H).

7.29 (s, 4H).

The reaction was repeated on a larger scale as follows: The Grignard reagent was prepared by the addition of 2-(2-bromoethyl)-1,3-dioxolane (68g, 377mmol) in THF (100 mL) to magnesium powder (9.5 g, 395 mmol) in THF (600 mL) over 45 min while keeping the reaction temperature below 500 C by cooling with a water bath (10-20° C). The reaction mixture was stirred for 1 h after the addition. The Grignard reagent was then cooled to 10 to 150 C with an ice- water bath, followed by the addition of a solution of ethyl 2-(4-formlyphenyl)-2-methylpropionate (60 g, 272 mmol) in THF (20 mL) via syringe over 20 min.

The reaction was exothermic, and the inner temperature increased to 250 C, even though the flask was cooled with an ice-water bath. After the addition, the reaction mixture was stirred for 10 min

at 220 C. The reaction mixture was quenched with water (15 mL, caution!), then with saturated ammonium chloride solution (200 mL), and extracted with EtOAC (300 mL, 60mL). The extracts were combined and washed with water (30 mL), dried over Na2SO4, and evaporated. The crude product (92g 105% by weight) was used for the next step without purification.

Hydrolysis of Ethyl 2-[3-(1,3-Dioxolan-2-yl)-1- Hydroxy-Propylphenyl] - 2 -Methylpropionate: To a solution of ethyl 2-[3-(1,3-dioxolan-2-yl)-1-hydroxy- propylphenyl]-2-methylpropionate (0.34 g) in THF (5 mL) at 22 OC, 5% HCl (5 mL) was added. The reaction mixture was heated at reflux for 1 h. The reaction mixture was cooled to 22 OC extracted with EtOAc( 2 x 20 mL), and concentrated. The remaining oil residue was passed through a column of silica gel using EtOAc /hexane (3:7) to give a mixture (1:1) of cis and trans lactols (0.2 g, 68%) containing < 5% aldehyde determined by 1H NMR.

Alternate Hydrolysis of Ethyl 2-[3-(1,3- Dioxolan-2-yl)-1-Hydroxy-Propylphenyl]-2- Methylpropionate: To a solution of ethyl 2-[3-(1,3- dioxolan-2-yl) -1-hydroxy-propylphenyl] -2- methylpropionate (90 g) in 900 mL of acetone at 22 OC was added 150 g of Amberlyst l5 in the H+ form and 180 mL of water. The reaction mixture was degassed and heated to 500C for 13 hours under argon atmosphere. The reaction mixture was concentrated to remove the solvent and the residue extracted with EtOAc (80 mL), washed with water (2 x 150 mL) and concentrated to give 79 g of oil. Proton NMR analysis of the oil indicated 77% product, 14% starting material and 8% of a partially hydrolyzed

by-product. The residue was redissolved in 600 mL of acetone to which 100 g of Amberlyst 15 and 150 mL of water were added. The mixture was heated at 400-450C for 60 hours, and worked up as before to provide 77 g of product pure enough for use in the next step. If desired it may be passed through a column of silica gel using EtOAc /hexane (3:7) to give a mixture (1:1) of cis and trans lactols in 85% yield. The lactol contains less than 5% of the tautomeric aldehyde as determined by 1H NMR.

Ethyl 4-[1-Hydroxy-4-[4-(Hydroxydiphenylmethyl)- 1-Piperidinyl]butyl]-a,-Dimethylbenzeneacetate: To a solution of the mixture of cis/trans lactols from above (4.8 g) in methanol (100 mL), a,-diphenyl-4- piperidinomethanol (4.1 g ) was added. The reaction mixture was heated to 750C for 1 h. The reaction solution was then cooled with an ice-water bath to 4 OC, and sodium borohydride (0.75 g) was added over 5 min period. The reaction mixture was stirred at 22 OC for 30 min . The reaction was quenched by addition of water (10 mL) and concentrated to remove the solvent. The residue was dissolved in water (50 mL) and extracted with EtOAc (60 mL), the organic phase was concentrated, the crude product was passed through a short column of silica gel (EtOAc/hexane 3:7) to give desired product (4.5 g). 'H NMR (CDCl3) d 1.12-1.17 (t, J = 7.1 Hz), 1.53 (s, 6H), 1.40-1.80 (m, 6H), 1.88-2.10 (m, 4H), 2.3-2.50 (m, 4H), 2.93- 2.96 (d, J =10 Hz, lH) , 3.11-3.15 (d, J =11 Hz), 4.04-4.11 (q, J = 7.3 Hz, 2H), 4.56-4.59 (dd, J1 = 2.7 Hz, J2 = 8.4 Hz, 1H), 7.15-7.18 (m, 2H), 7.25- 7.30 (m, 8H), 7.45-7.50 (m, 4H).

The foregoing reaction was repeated on a larger scale as follows:

To a solution of the mixture cis/trans (77 g crude 0.200 mol) in methanol (650 mL) was added oL,OL- diphenyl-4-piperidinemethanol (55 g, 0.206 mol). The reaction mixture was heated at 500 C for 1 h (A clear solution was obtained). The reaction solution was then cooled with an ice-water bath to 10 to 150 C, and sodium borohydride (15 g,) was added over 15 min.

The reaction was exothermic and the inner temperature rose to 400 C. The reaction mixture was stirred for 30 min after the addition of NaBH4. The reaction was quenched by addition of water (10 mL), and concentrated to remove the solvent to give a solid residue. It was suspended in water (500 mL) and extracted with ethyl acetate (400 mL, 200mL). The combined organic phases were washed with water (100 mL), brine (50 mL), dried over Na2SO4 for 1 h, filtered, the filtrate was concentrated to give a thick oil which contained about 50 mL of EtOAc. To it was added hexane (400 mL) with stirring, and a white precipitate was collected by filtration. The solid was washed with hexane (60 mL and dried to give 105 g crude product (91% pure by HPLC, 66.4% overall yield from the aldehyde). The crude product was used for next step, or could be purified by passing through a short column of silica gel (EtOAc) to give the desired product (85%).

4-[1-Hydroxy-4-[4-(Hydroxydiphenylmethyl)-1- Piperidinyl]butyl]-a,-Dimethylbenzeneacetic Acid: Ethyl 4- [1-hydroxy-4- [4- (hydroxydiphenylmethyl) -1- piperidinyl]butyl]-a,-dimethylbenzeneacetate (0.5 g) was dissolved in MeOH (10 mL), and sodium hydroxide solution (0.35 g, water 3 mL) was added. The reaction mixture was heated at reflux for 5 h, and cooled to 22 OC, followed by the addition of acetic

acid to reach a pH 4-5. MeOH (5 mL) was added to the solution and stirred for 1 h. The precipitate was collected by filtration to give 0.42 g of 4-[4-[4- (hydroxydiphenylmethyl)-1-piperidinyl]-1- hydroxybutyl]-a,-dimethylbenzeneacetic acid. 1H NMR (DMSO-d6) d 1.45-1.49(m, 2H), 1.67 (s, 6H), 1.67-1.78 (m, 6H), 2.12-2.20 (m, 2H), 2.45-2.50 (m, 2H), 2.68- 2.78 (m 3H), 3.10 (broad s, 2H) , 4.71 (m, 1H), 5.50 (broad s, 1H), 7.35 -7.40 (m, 2H), 7.45-7.55 (m, 8H), 7.76-7.78 (m, 4H). MH+ 502.3 The foregoing reaction was repeated on a larger scale as follows: Ethyl 4- [1-hydroxy-4- [4- (hydroxydiphenylmethyl) - 1-piperidinyl]butyl]-a/a-dimethylbenzeneacetate (crude, 104 g, 196 mmol) was dissolved in MeOH (1 L), and sodium hydroxide solution (40 g, water 400 mL) was added. The reaction mixture was heated at reflux for 3 h, and cooled to 220 C, followed by addition of acetic acid (65 mL) to reach pH 4-5. A white precipitate appeared. The suspension was cooled to 0 to 50 C and filtered and washed with water (60 mL) to yield a wet cake (160 g, 97.43% area by HPLC). The wet cake was transferred to a 2L flask, methanol was added (1.5 L), heated to reflux for 20 min, cooled to rt overnight, and filtered to collected the solid as wet cake (133 g). It was dried to give the product (80g, 89% yield, cp 99.51%).

Fexofenadine HCl salt: To a suspension of ethyl 4- [1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1- piperidinyl]butyl]-a,-dimethylbenzeneacetate (80 g, 0.160 mol) in MeOH (200 mL) was added to a solution of HCl (1.57 M, 120 mL) at 0 to 50 C (the salt

formation was not exothermic, a clear solution was obtained). The reaction mixture was concentrated to remove most of the solvent (ca 250 mL) to give a thick oil. To it was added water (300 mL) to give a suspension, which was stirred to 15 min, heated to 55 to 600 C for 15 min (the suspension remained), and cooled to rt overnight, then 0 to 50 C for 2 h, filtered, and the wet cake washed with ethyl acetate (40 mL). The hydrochloride salt (78 g 90%) was obtained after drying the wet cake for 50 h at 45 to 500 C under vacuum (1 mm Hg), cp. 99.4%, LOD 0.79 (50 to 1500 C).

Ethyl 2-[4-[3-(1,3-Dioxolan-2-yl)]-1- Oxopropyl]phenyl-2-Methylpropionate: To 4g of ethyl 2-[4-[3-(1,3-dioxolan-2-yl)]-1- hydroxy-propylphenyl]-2-methylpropionate (4g, 12.5 mmol) in dichloromethane (50 mL) was added PDC (6.9 g) at rt. The reaction mixture was stirred for 15 h, and filtered through celite, the filtrate was concentrated to give a residue, which was passed through a short column of silica gel using EtOAc/hexane (4:6) as eluate to give 3.4 g (10.5 mmol) title product (84%). 'H NMR (CDCl3)6 1.16-1.20 (t, J=7.1 Hz, 3H), 1.59 (s, 6H), 2.10-2.17 (m, 2H), 3.08-3.13 (t, J=6.3 Hz, 1H), 3.86-3.98 (m, 4H), 4.09- 4.16 (q, J=7.1 Hz, 2H), 5.03 (t, J=4.5 Hz, 1H), 7.41- 7.44 (d, J=8.7 Hz), 7.94-7.97 (d, J=8.7 Hz, 2H). 13C 6 13.93, 26.27, 27.88, 32.38, 46.68, 60.92, 64.90, 103.35, 125.85, 128.10, 135.20, 149.94, 175.95, 198.74.

Ethyl 2-[4-(3-Formyl-1-0xopropyl)lphenyl-2- Methylpropionate: Ethyl 2-[3-(ls3-dioxolan-2-yl)-l-oxopropylphenyl]-2

methylpropinate (0.31 g, 1 mmol) was dissolved in acetone (8 mL), followed by addition of 5% HCl (8 mL). The reaction mixture was stirred at rt for 5 h, and concentrated to remove acetone, the residue was extracted with ethyl acetate (10 mL), washed with water, brine, and concentrated to give the title compound (0.27 g, 1 mmol). 1H NMR (CDCl3) b 1.16-1.21 (t, J=7.1 Hz, 3H), 1.59 (s, 6H), 2.91-2.95 (t, J= 6.3 Hz, 2H), 3.29-3.33 (t, J=6.3 Hz, 2H), 409-4.17 (q, J= 7.1 Hz, 2H), 7.43-7.46 (d, J=8.7 Hz), 7.94-7.97 (d, J=8.7 Hz, 2H). 13 C 6 13.86, 26.19, 30.82, 37.42, 46.64, 60.88, 125.89, 128.06, 134.66, 150.26, 175.82, 197.17, 200.49 Ethyl 2-(4-carboxylphenyl)-2-Methylpropionate: A solution of ethyl 2-(4-formylphenyl)-2- methylpropionate (1 g) in EtOAc (5 mL) was stirred in air for 24 h. The solvent was then removed to give a crude colorless solid as title compound (1 g). 1H NMR (CDCl3) b 1.16-1.21 (t, J=7.1 Hz, 3H), 1.61 (s, 6H), 4.10-4.17 (q, J=7.1 Hz, 2H), 7.44-7.47 (d, J=8.7 Hz), 8.07-8.09 (d, J=8.7 Hz, 2H), 12.0 (broad s, 1H). 13C b 13.89, 26.25, 46.77, 61.02, 125.82, 130.21, 150.80, 171.80, 176.03, 191.95.

Alternate Synthesis of Ethyl 4-[1-Hydroxy-4-[4- (Hydroxydiphenylmethyl)-1-Piperidinyl]butyl]a,- Dimethylbenzeneacetate from ethyl 2- [4- (3-formyl-1- oxopropyl) ] phenyl - 2 -methylpropionate: Employing the same procedure as described about but replacing lactol (IVb) with ethyl 2- [4- [3-formyl-l- oxopropyl] phenyl] -2-methylpropionate as the starting material for the reductive amination, the title compound may be prepared.