SYNTHETIC METHOD FOR CETYL-PG HYDROXYETHYL PALMITAMIDE

WIPO Patent Application WO/2023/060955

A1

Provided in the present invention is a synthetic method for cetyl-PG hydroxyethyl palmitamide. The method comprises the following steps: firstly, mixing 1,3-dichloropropanol and hexadecyl alcohol under the action of a catalyst and an alkali to obtain hexadecyl glycidyl ether, then reacting the ether with ethanolamine to obtain a secondary amine derivative, and finally, reacting the derivative with methyl palmitate to obtain cetyl-PG hydroxyethyl palmitamide. The method of the present invention is low in terms of cost, easy and safe to operate, simple, and has a high yield.

LI XIAOHU (CN)
ZHANG MIN (CN)
QIAN JIA (CN)
CHENG WEIFENG (CN)
ZHANG WEIYANG (CN)
CHEN XIAO (CN)

PCT/CN2022/105256

April 20, 2023

July 12, 2022

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SHANGHAI OLI ENTPR CO LTD (CN)
SHANGHAI OLI BIO TECH CO LTD (CN)

C07C231/02; C07C213/04; C07C217/28; C07C233/18; C07D303/22

CN112321445A	2021-02-05
CN112441937A	2021-03-05

SUN JINYUAN, KANG BAO-AN, SUN YONG-QIANG, YANG HUI-YAN, WU HUA-PING: "Synthesis of Lauryl Glycidyl Ether", CHINA SURFACTANT DETERGENT & COSMETICS, QINGGONGYE-BU KEXUE JISHU QINGBAO YANJIUSUO, CN, vol. 42, no. 2, 30 April 2012 (2012-04-30), CN , pages 111 - 114, XP093059121, ISSN: 1001-1803, DOI: 10.13218/j.cnki.csdc.2012.02.011
SUN JIN-YUAN, KANG BAO-AN, WU HUA-PING, YANG HUI-YAN, ZHOU XI-YANG: "Synthesis of Dodecyl Glycidyl Ether by Phase Transfer Catalysis", FINE CHEMICALS, vol. 28, no. 9, 30 September 2011 (2011-09-30), pages 930 - 932, XP093059124, ISSN: 1003-5214, DOI: 10.13550/j.jxhg.2011.09.015

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