Title:
SYNTHETIC PEPTIDE CAPABLE OF INDUCING EXPRESSION OF TYPE-2 TNF RECEPTOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/150676
Kind Code:
A1
Abstract:
Provided are: a composition for inducing the expression of TNFR2, which contains a peptide having a high activity of inducing the expression of TNFR2 as an active ingredient; and a method for producing a cell that expresses TNFR2 in a selective manner, which utilizes the composition. The method for producing the cell provided according to the present invention comprises: a step of culturing a cell capable of expressing at least one type-2 TNF receptor; and a step of supplying a synthetic peptide comprising a nuclear localization signal sequence (NLS) or a nucleolus localization signal sequence (NoLS) to the cell to increase the expression amount of the type-2 TNF receptor in the cell.
Inventors:
KOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)
NIWA MIKIO (JP)
YOSHIDA TETSUHIKO (JP)
NIWA MIKIO (JP)
Application Number:
PCT/JP2012/060369
Publication Date:
November 08, 2012
Filing Date:
April 17, 2012
Export Citation:
Assignee:
TOAGOSEI CO LTD (JP)
KOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)
NIWA MIKIO (JP)
KOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)
NIWA MIKIO (JP)
International Classes:
A61K38/00; C12N5/10; A61P43/00; C07K14/47; A61P5/50; A61P9/00; A61P25/28
Domestic Patent References:
| WO2008081812A1 | 2008-07-10 | |||
| WO2009093692A1 | 2009-07-30 |
Other References:
ABU-AMER, Y. ET AL.: "Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 35, 1 September 2000 (2000-09-01), pages 27307 - 27310, XP055132175
HIROSHI KANNO ET AL.: "Gosei Peptide no Saibonai Donyu ni yoru Kansaibo no Koritsuteki na Shinkei Bunka to sono Saisei Iryo eno Oyo", YOKOHAMA IGAKU, vol. 60, no. L, 2, 30 May 2009 (2009-05-30), pages 111 - 115, XP008171388
THE AMERICAN JOURNAL OF PATHOLOGY, vol. 169, no. 5, 2006, pages 1886 - 1898
NATURE REVIEWS DRUG DISCOVERY, vol. 9, 2010, pages 482 - 493
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 30, 2010, pages 1307 - 1314
THE JOURNAL OF CELL BIOLOGY, vol. 178, no. 5, 2007, pages 829 - 841
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 95, 1995, pages 2409 - 2415
NUCLEIC ACIDS RESEARCH, vol. 38, no. 21, 2010, pages 7388 - 7399
EMBO REPORTS, vol. 10, no. 3, 2009, pages 231 - 238
PLOS ONE, vol. 6, no. 11, January 2011 (2011-01-01), pages E27621
SHIMIZU ET AL., NATURE BIOTECHNOLOGY, vol. 19, 2001, pages 751 - 755
MADIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, no. 2, 2000, pages 559 - 564
CORWIN HANSCH: "Comprehensive Medicinal Chemistry", 1990, PERGAMON PRESS
See also references of EP 2706113A4
HIROSHI KANNO ET AL.: "Gosei Peptide no Saibonai Donyu ni yoru Kansaibo no Koritsuteki na Shinkei Bunka to sono Saisei Iryo eno Oyo", YOKOHAMA IGAKU, vol. 60, no. L, 2, 30 May 2009 (2009-05-30), pages 111 - 115, XP008171388
THE AMERICAN JOURNAL OF PATHOLOGY, vol. 169, no. 5, 2006, pages 1886 - 1898
NATURE REVIEWS DRUG DISCOVERY, vol. 9, 2010, pages 482 - 493
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 30, 2010, pages 1307 - 1314
THE JOURNAL OF CELL BIOLOGY, vol. 178, no. 5, 2007, pages 829 - 841
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 95, 1995, pages 2409 - 2415
NUCLEIC ACIDS RESEARCH, vol. 38, no. 21, 2010, pages 7388 - 7399
EMBO REPORTS, vol. 10, no. 3, 2009, pages 231 - 238
PLOS ONE, vol. 6, no. 11, January 2011 (2011-01-01), pages E27621
SHIMIZU ET AL., NATURE BIOTECHNOLOGY, vol. 19, 2001, pages 751 - 755
MADIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, no. 2, 2000, pages 559 - 564
CORWIN HANSCH: "Comprehensive Medicinal Chemistry", 1990, PERGAMON PRESS
See also references of EP 2706113A4
Attorney, Agent or Firm:
ABE MAKOTO (JP)
Makoto Abe (JP)
Makoto Abe (JP)
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