Title:
SYNTHETIC PLATELETS
Document Type and Number:
WIPO Patent Application WO/2012/142362
Kind Code:
A3
Abstract:
A synthetic platelet includes a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides conjugated to the surface, the peptides including a plurality of von Willebrand factor-binding peptides (VBPs), collagen-binding peptides (CBPs) and an active platelet GPIIb-IIIa-binding peptides (GBPs).
Inventors:
SEN GUPTA ANIRBAN (US)
RAVIKUMAR MADHUMITHA (US)
RAVIKUMAR MADHUMITHA (US)
Application Number:
PCT/US2012/033444
Publication Date:
January 10, 2013
Filing Date:
April 13, 2012
Export Citation:
Assignee:
UNIV CASE WESTERN RESERVE (US)
SEN GUPTA ANIRBAN (US)
RAVIKUMAR MADHUMITHA (US)
SEN GUPTA ANIRBAN (US)
RAVIKUMAR MADHUMITHA (US)
International Classes:
C07K17/02; A61K9/127; C12N5/078
Domestic Patent References:
| WO2010008792A1 | 2010-01-21 |
Foreign References:
| US20080213369A1 | 2008-09-04 | |||
| US20070059376A1 | 2007-03-15 |
Other References:
PUGH, N. ET AL.: "Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood", BLOOD, vol. 115, no. 24, 29 March 2010 (2010-03-29), pages 5069 - 5079, XP002693780, DOI: doi:10.1182/blood-2010-01-260778
RAVIKUMAR, M. ET AL.: "Peptide-Decorated Liposomes Promote Arrest and Aggregation of Activated Platelets under Flow on Vascular Injury Relevant Protein Surfaces in Vitro", BIOMACROMOLECULES, vol. 13, 3 April 2012 (2012-04-03), pages 1495 - 1502
SRINIVASAN, R. ET AL.: "In vitro and in vivo platelet targeting by cyclic RGD-modified liposomes", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 93, 9 September 2009 (2009-09-09), pages 1004 - 1015
RAVIKUMAR, M. ET AL.: "Peptide-Decorated Liposomes Promote Arrest and Aggregation of Activated Platelets under Flow on Vascular Injury Relevant Protein Surfaces in Vitro", BIOMACROMOLECULES, vol. 13, 3 April 2012 (2012-04-03), pages 1495 - 1502
SRINIVASAN, R. ET AL.: "In vitro and in vivo platelet targeting by cyclic RGD-modified liposomes", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 93, 9 September 2009 (2009-09-09), pages 1004 - 1015
Attorney, Agent or Firm:
SUTKUS, Richard A. (Sundheim Covell & Tummino LLP,1300 East Ninth Street,Suite 170, Cleveland OH, US)
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