Title:
SYNTHETIC T CELL RECEPTOR AND ANTIGEN RECEPTOR SPECIFICALLY BINDING TO MESOTHELIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/078431
Kind Code:
A1
Abstract:
A synthetic T cell receptor and antigen receptor specifically binding to mesothelin and the use thereof. TCR and CAR are modified with an antigen-binding fragment targeting MSLN, which results in a better tumor treatment effect.
Inventors:
LIN XIN (CN)
RUI WEI (CN)
YU LI (CN)
WU CHUNYAN (CN)
ZHAO XUEQIANG (CN)
RUI WEI (CN)
YU LI (CN)
WU CHUNYAN (CN)
ZHAO XUEQIANG (CN)
Application Number:
PCT/CN2022/130106
Publication Date:
May 11, 2023
Filing Date:
November 04, 2022
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
BRISTAR IMMUNOTECH LTD (CN)
BRISTAR IMMUNOTECH LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C12N7/01; C12N15/62
Domestic Patent References:
| WO2018166589A1 | 2018-09-20 |
Foreign References:
| CN110818802A | 2020-02-21 | |||
| CN108715616A | 2018-10-30 | |||
| CN109641948A | 2019-04-16 | |||
| CN108864310A | 2018-11-23 | |||
| CN109111528A | 2019-01-01 | |||
| CN111499767A | 2020-08-07 |
Other References:
DUAN, AIJUN ET AL.: "Advances in Mesothelin-Targeted Anticancer Therapy", CHINESE MEDICINAL BIOTECHNOLOGY, vol. 14, no. 03, 30 June 2019 (2019-06-30), XP009546060
ADUSUMILLI PRASAD S., ZAUDERER MARJORIE G., RIVIÈRE ISABELLE, SOLOMON STEPHEN B., RUSCH VALERIE W., O'CEARBHAILL ROISIN E., ZHU AM: "A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 11, no. 11, 1 November 2021 (2021-11-01), US , pages 2748 - 2763, XP093047614, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-21-0407
KLAMPATSA ASTERO, DIMOU VIVIAN, ALBELDA STEVEN M.: "Mesothelin-targeted CAR-T cell therapy for solid tumors", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 21, no. 4, 3 April 2021 (2021-04-03), pages 473 - 486, XP093054525, ISSN: 1471-2598, DOI: 10.1080/14712598.2021.1843628
ADUSUMILLI PRASAD S., ZAUDERER MARJORIE G., RIVIÈRE ISABELLE, SOLOMON STEPHEN B., RUSCH VALERIE W., O'CEARBHAILL ROISIN E., ZHU AM: "A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 11, no. 11, 1 November 2021 (2021-11-01), US , pages 2748 - 2763, XP093047614, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-21-0407
KLAMPATSA ASTERO, DIMOU VIVIAN, ALBELDA STEVEN M.: "Mesothelin-targeted CAR-T cell therapy for solid tumors", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, vol. 21, no. 4, 3 April 2021 (2021-04-03), pages 473 - 486, XP093054525, ISSN: 1471-2598, DOI: 10.1080/14712598.2021.1843628
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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