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Title:
SYNTHETIC TUMOR-INFILTRATING LYMPHOCYTES (TILS)
Document Type and Number:
WIPO Patent Application WO/2023/174398
Kind Code:
A1
Abstract:
The present disclosure provides compositions and methods for producing modified cells (e.g., synthetic tumor-infiltrating lymphocytes or TILs). The modified cells can be used to prepare a pharmaceutical composition to be administered into a subject in need thereof. The modified cells can be polyclonal TCR-T cells expressing two or more different subject-specific T-cell receptors (TCRs).

Inventors:
ZHAO YUE (CN)
XUAN JIEKUN (CN)
JIAO SHIPING (CN)
XIONG QING (CN)
Application Number:
PCT/CN2023/082120
Publication Date:
September 21, 2023
Filing Date:
March 17, 2023
Export Citation:
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Assignee:
ROOTPATH INC (KY)
KESHIHUA NANJING BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/10; A61K38/17; A61P35/00
Domestic Patent References:
WO2021101956A12021-05-27
Foreign References:
US20180282808A12018-10-04
CN109715669A2019-05-03
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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