SYSTEMS AND METHODS FOR AUTOMATED VOXELATION OF REGIONS OF INTEREST FOR MAGNETIC RESONANCE SPECTROSCOPY

Title:

SYSTEMS AND METHODS FOR AUTOMATED VOXELATION OF REGIONS OF INTEREST FOR MAGNETIC RESONANCE SPECTROSCOPY

Document Type and Number:

WIPO Patent Application WO/2012/071566

Kind Code:

A3

Abstract:

A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).

Inventors:

CLAUDE JOHN P (US)
PEACOCK JAMES C (US)
KANE PAUL H (US)

Application Number:

PCT/US2011/062137

Publication Date:

October 11, 2012

Filing Date:

November 23, 2011

Export Citation:

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Assignee:

NOCIMED LLC (US)
CLAUDE JOHN P (US)
PEACOCK JAMES C (US)
KANE PAUL H (US)

International Classes:

A61B5/055

Foreign References:

US20050240104A1	2005-10-27
US20100268225A1	2010-10-21
US20100086185A1	2010-04-08

Other References: