Title:
SYSTEMS AND METHODS FOR IDENTIFYING AND TARGETING COLLATERAL LETHAL GENES
Document Type and Number:
WIPO Patent Application WO/2024/064810
Kind Code:
A3
Abstract:
Provided herein are systems and methods for identifying collateral lethal genes via metabolic fluxes and the use of such genes for the identification of, selections of, and use of therapeutic agents. Further provided herein are identified targets, such as MTHFD2, that may be regulated to treat or prevent diseases and conditions.
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Inventors:
ANIMASAHUN OLAMIDE (US)
WUCHU FULEI (US)
NENWANI MINAL (US)
ACHREJA ABHINAV (US)
NAGRATH DEEPAK (US)
WUCHU FULEI (US)
NENWANI MINAL (US)
ACHREJA ABHINAV (US)
NAGRATH DEEPAK (US)
Application Number:
PCT/US2023/074767
Publication Date:
May 02, 2024
Filing Date:
September 21, 2023
Export Citation:
Assignee:
UNIV MICHIGAN REGENTS (US)
International Classes:
G16B5/00; A61P35/00; C12N9/02; C12N9/06; C12N9/78; G16B20/10
Foreign References:
| US20210155932A1 | 2021-05-27 | |||
| US20160117440A1 | 2016-04-28 |
Other References:
PRASENJIT DEY: "Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer", NATURE, SPRINGER NATURE LIMITED, vol. 542, no. 7639, 20 April 2017 (2017-04-20), pages 119 - 123, XP093167779, ISSN: 0028-0836, DOI: 10.1038/nature21052
ABHINAV ACHREJA: "Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer", NATURE METABOLISM, vol. 4, no. 9, pages 1119 - 1137, XP093167780, ISSN: 2522-5812, DOI: 10.1038/s42255-022-00636-3
ABHINAV ACHREJA: "Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer", NATURE METABOLISM, vol. 4, no. 9, pages 1119 - 1137, XP093167780, ISSN: 2522-5812, DOI: 10.1038/s42255-022-00636-3
Attorney, Agent or Firm:
CASIMIR, David A. (US)
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