Title:
T-CELL RECEPTOR EXPRESSED BY HUMAN T-CELLS THAT RECOGNIZE PEPTIDE DERIVED FROM URLC10 OR PEPTIDE DERIVED FROM DEPDC1
Document Type and Number:
WIPO Patent Application WO/2021/060343
Kind Code:
A1
Abstract:
The present invention provides a T-cell receptor (TCR) that has URLC10- or DEPDC1-specific HLA-A24-restricted cytotoxic activity. Introducing this TCR into T cells makes it possible to produce cytotoxic T cells (CTL) that can be used to treat cancer. This TCR can also be used to monitor immune response in subjects that have been inoculated with a URLC10 or DEPDC1 peptide vaccine.
Inventors:
PARK JAE-HYUN (JP)
YAMASHITA SACHIKO (JP)
HIKICHI TETSURO (JP)
IDE NOBUYUKI (JP)
NAGIRA MORIO (JP)
DOHI KEIJI (JP)
YAMASHITA SACHIKO (JP)
HIKICHI TETSURO (JP)
IDE NOBUYUKI (JP)
NAGIRA MORIO (JP)
DOHI KEIJI (JP)
Application Number:
PCT/JP2020/035947
Publication Date:
April 01, 2021
Filing Date:
September 24, 2020
Export Citation:
Assignee:
ONCOTHERAPY SCIENCE INC (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
A61K48/00; A61K35/17; A61K35/76; A61P35/00; C07K14/725; C12N5/0783; C12N5/10; C12N5/16; C12N15/12; C12N15/63; C12Q1/02; C12Q1/6869
Domestic Patent References:
| WO2008108257A1 | 2008-09-12 |
Foreign References:
| JP2008530975A | 2008-08-14 | |||
| JP2010506826A | 2010-03-04 | |||
| JP2018070540A | 2018-05-10 |
Other References:
MATSUDA T. ET AL.: "Personalized immunotherapies using onconatigen/ neoantigen-reactive TCR-engineered T cells", ANNUAL ACADEMIC GENERAL CONFERENCE JAPANESE CANCER ASSOCIATION, vol. 76, 2017, pages 837
AKATSUKA Y. ET AL: "IV. T-cell receptor-engineered T cells", NIHON NAIKA GAKKAI ZASSHI, vol. 108, no. 7, 10 July 2019 (2019-07-10), pages 1384 - 1390
KIYOTANI K. ET AL.: "TCR sequencing analysis of cancer tissues and lymph nodes in colorectal cancer patients", CANCER SCIENCE, vol. 109, no. S2, 2018, pages 1091, XP055792081
AKATSUKA Y. ET AL: "IV. T-cell receptor-engineered T cells", NIHON NAIKA GAKKAI ZASSHI, vol. 108, no. 7, 10 July 2019 (2019-07-10), pages 1384 - 1390
KIYOTANI K. ET AL.: "TCR sequencing analysis of cancer tissues and lymph nodes in colorectal cancer patients", CANCER SCIENCE, vol. 109, no. S2, 2018, pages 1091, XP055792081
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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