Title:
T CELL RECEPTOR FOR RECOGNIZING RHAMM ANTIGEN SHORT-CHAIN POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2016/177195
Kind Code:
A1
Abstract:
Provided in the present invention is a T cell receptor (TCR) capable of binding specifically antigen short-chain polypeptide ILSLELMKL derived from RHAMM. The antigen short-chain polypeptide ILSLELMKL is capable of forming a complex with HLA A0201 and being presented together on the surface of a cell. Also provided in the present invention are a nucleic acid molecule encoding the TCR and a vector comprising the nucleic acid molecule. In addition, also provided in the present invention is a cell for transducing the TCR of the present invention.
Inventors:
LI YI (CN)
LIN YANMEI (CN)
WU WANLI (CN)
LIN YANMEI (CN)
WU WANLI (CN)
Application Number:
PCT/CN2016/077679
Publication Date:
November 10, 2016
Filing Date:
March 29, 2016
Export Citation:
Assignee:
GUANGZHOU XIANGXUE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/725; A61K35/17; A61K38/17; A61K48/00; A61P35/00; A61P35/02; A61P37/02; C12N5/10; C12N15/12; C12N15/867
Foreign References:
| CN103619882A | 2014-03-05 |
Other References:
GREINER, J. ET AL.: "Identification and Characterization of Epitopes of the Receptor for Hyaluronic Acid-mediated Motility (RHAMM/ CD 168) Recognized by CD 8+T Cells ofpo.A2. HLAsitive Patients with Acute Myeloid Leukemia", BLOOD, vol. 106, no. 3, 1 August 2005 (2005-08-01), pages 938 - 945, XP055329472
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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