Title:
T-CELL RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2023/249071
Kind Code:
A1
Abstract:
[Problem] To provide a novel T-cell receptor (TCR) which specifically recognizes glypican 3 (GPC3). [Solution] Provided is a T-cell receptor (TCR) that includes one amino acid sequence selected from the group consisting of the amino acid sequences represented by sequence numbers 1-13 as a complementarity determining region of an α chain, and that includes one amino acid sequence selected from the group consisting of the amino acid sequences represented by sequence numbers 14-28 as a complementarity determining region of a β chain.
Inventors:
NAKATSURA TETSUYA (JP)
YOSHIKAWA TOSHIAKI (JP)
HITOSHI YASUMICHI (JP)
OSAWA MITSUJIRO (JP)
YOSHIKAWA TOSHIAKI (JP)
HITOSHI YASUMICHI (JP)
OSAWA MITSUJIRO (JP)
Application Number:
PCT/JP2023/023069
Publication Date:
December 28, 2023
Filing Date:
June 22, 2023
Export Citation:
Assignee:
NAT CANCER CT (JP)
THYAS CO LTD (JP)
THYAS CO LTD (JP)
International Classes:
A61K35/17; C07K14/725; A61K35/545; A61P1/16; A61P35/00; C12N5/0783; C12N5/10; C12N15/12; C12N15/63
Domestic Patent References:
| WO2022059780A1 | 2022-03-24 | |||
| WO2022056321A1 | 2022-03-17 | |||
| WO2022220146A1 | 2022-10-20 |
Foreign References:
| JP2017522859A | 2017-08-17 | |||
| JP2020517294A | 2020-06-18 |
Other References:
NOBUHIRO TSUCHIYA, TOSHIAKI YOSHIKAWA, NORIHIRO FUJINAMI, KEIGO SAITO, SHOICHI MIZUNO, YU SAWADA, ITARU ENDO, TETSUYA NAKATSURA: "Immunological efficacy of glypican-3 peptide vaccine in patients with advanced hepatocellular carcinoma", ONCOIMMUNOLGY, LANDES BIOSCIENCE, US, vol. 6, no. 10, 3 October 2017 (2017-10-03), US , pages 1 - 11, XP055742966, ISSN: 2162-4011, DOI: 10.1080/2162402X.2017.1346764
NAKATSURA, TETSUYA ET AL.: "TCR-T Cells and CAR-T Cells Targeted Against Glypican-3 Antigen − Which Is More Promising?", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 275, no. 1, 1 January 2020 (2020-01-01), JP , pages 26 - 33, XP009551855, ISSN: 0039-2359
NAKATSURA, TETSUYA: "Peptide-Based Vaccines for Cancer Targeted Against Glypican-3 Antigen", JAPANESE JOURNAL OF CLINICAL MEDICINE, NIPPON-RINSHO CO., OSAKA., JP, vol. 75, no. 2, 1 January 2017 (2017-01-01), JP , pages 257 - 262, XP009551460, ISSN: 0047-1852
HERVAS-STUBBS, S. ET AL.: "Identification of a T-cell receptor specific for glypican 3 for adoptive immunotherapy", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 30, no. 12, 19 September 2019 (2019-09-19), GB , pages A15, XP009551856, ISSN: 1043-0342
NAKATSURA, TETSUYA ET AL.: "TCR-T Cells and CAR-T Cells Targeted Against Glypican-3 Antigen − Which Is More Promising?", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 275, no. 1, 1 January 2020 (2020-01-01), JP , pages 26 - 33, XP009551855, ISSN: 0039-2359
NAKATSURA, TETSUYA: "Peptide-Based Vaccines for Cancer Targeted Against Glypican-3 Antigen", JAPANESE JOURNAL OF CLINICAL MEDICINE, NIPPON-RINSHO CO., OSAKA., JP, vol. 75, no. 2, 1 January 2017 (2017-01-01), JP , pages 257 - 262, XP009551460, ISSN: 0047-1852
HERVAS-STUBBS, S. ET AL.: "Identification of a T-cell receptor specific for glypican 3 for adoptive immunotherapy", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 30, no. 12, 19 September 2019 (2019-09-19), GB , pages A15, XP009551856, ISSN: 1043-0342
Attorney, Agent or Firm:
SHA PATENT AND TRADEMARK FIRM (JP)
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