Title:
T-CELL RECEPTORS DIRECTED AGAINST THE PREFERENTIALLY EXPRESSED ANTIGEN OF MELANOMA AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/142783
Kind Code:
A3
Abstract:
The technology relates in part to compositions and methods for inducing an immune response against the Preferentially Expressed Antigen of Melanoma (PRAME). Provided are methods for treating hyperproliferative diseases by inducing an immune response against PRAME antigen; the immune response may be induced by specifically targeting PRAME-expressing cells using T cell receptors directed against PRAME.
Inventors:
FALKENBURG J H FREDERIK (NL)
HEEMSKERK MIRJAM H M (NL)
HEEMSKERK MIRJAM H M (NL)
Application Number:
PCT/IB2016/000399
Publication Date:
November 10, 2016
Filing Date:
March 09, 2016
Export Citation:
Assignee:
LEIDEN UNIV MEDICAL CENTER (NL)
International Classes:
A61K35/17; A61P35/00; C07K14/725; C12N15/85; C07K16/30
Domestic Patent References:
| WO2011062634A2 | 2011-05-26 | |||
| WO2014197638A2 | 2014-12-11 | |||
| WO2013040371A2 | 2013-03-21 |
Other References:
AMIR AVITAL L ET AL: "PRAME-specific Allo-HLA-restricted T cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 SEP 2011, vol. 17, no. 17, 1 September 2011 (2011-09-01), pages 5615 - 5625, XP002760143, ISSN: 1078-0432
VAN LOENEN M M ET AL: "Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells.", GENE THERAPY AUG 2013, vol. 20, no. 8, August 2013 (2013-08-01), pages 861 - 867, XP002760144, ISSN: 1476-5462
DOSSETT MICHELLE L ET AL: "Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY APR 2009, vol. 17, no. 4, April 2009 (2009-04-01), pages 742 - 749, XP002760145, ISSN: 1525-0024
VAN LOENEN M M ET AL: "Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells.", GENE THERAPY AUG 2013, vol. 20, no. 8, August 2013 (2013-08-01), pages 861 - 867, XP002760144, ISSN: 1476-5462
DOSSETT MICHELLE L ET AL: "Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY APR 2009, vol. 17, no. 4, April 2009 (2009-04-01), pages 742 - 749, XP002760145, ISSN: 1525-0024
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