Title:
T CELL SYNERGIST FOR CAR T CELL THERAPY FOR LEUKEMIA AND METHOD FOR OBTAINING SYNERGISTIC T CELLS
Document Type and Number:
WIPO Patent Application WO/2022/088555
Kind Code:
A1
Abstract:
Provided are a T cell synergist for use in CAR T cell therapy for hematological tumors such as acute myeloid leukemia, and a method for using same to enhance the effect of CAR T cell therapy. The method comprises treating T cells used in CAR T cell therapy during in vitro cultivation by using a PI3K-AKT/mTOR signaling pathway inhibitor as a T cell synergist. The T cell synergist may enhance the migration of CAR T/NK cells to the bone marrow and improve the effect of CAR T cell therapy on removing tumors.
Inventors:
WEI HAIMING (CN)
NIAN ZHIGANG (CN)
ZHENG XIAOHU (CN)
SUN RUI (CN)
TIAN ZHIGANG (CN)
NIAN ZHIGANG (CN)
ZHENG XIAOHU (CN)
SUN RUI (CN)
TIAN ZHIGANG (CN)
Application Number:
PCT/CN2021/076819
Publication Date:
May 05, 2022
Filing Date:
February 19, 2021
Export Citation:
Assignee:
UNIV SCIENCE & TECHNOLOGY CHINA (CN)
International Classes:
C12N5/0783; A61K31/436; A61P35/00
Foreign References:
| CN108366995A | 2018-08-03 | |||
| CN109762788A | 2019-05-17 |
Other References:
WENTING ZHENG ET AL.: "PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells", LEUKEMIA, vol. 32, no. 5, 2 February 2018 (2018-02-02), XP036743476, ISSN: 1476-5551, DOI: 10.1038/s41375-017-0008-6
MOLLY R.PERKINSD.PHIL ET AL.: "Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells", BLOOD, vol. 126, no. 23, 3 December 2015 (2015-12-03), XP086645028, DOI: 10.1182/blood.V126.23.1893.1893
ALIZADEH DARYA, WONG ROBYN A., YANG XIN, WANG DONGRUI, PECORARO JOSEPH R., KUO CHENG-FU, AGUILAR BRENDA, QI YUE, ANN DAVID K., STA: "IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype", CANCER IMMUNOLOGY RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 5, 1 May 2019 (2019-05-01), US , pages 759 - 772, XP055776481, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-18-0466
CAO SIHENG: "The Antitumor Effects of CAR-T Cells Targeting EpCAM Antigen on Colorectal Cancer", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, no. 10, 15 October 2018 (2018-10-15), CN , XP055926330, ISSN: 1674-0246
MOLLY R.PERKINSD.PHIL ET AL.: "Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells", BLOOD, vol. 126, no. 23, 3 December 2015 (2015-12-03), XP086645028, DOI: 10.1182/blood.V126.23.1893.1893
ALIZADEH DARYA, WONG ROBYN A., YANG XIN, WANG DONGRUI, PECORARO JOSEPH R., KUO CHENG-FU, AGUILAR BRENDA, QI YUE, ANN DAVID K., STA: "IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype", CANCER IMMUNOLOGY RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 5, 1 May 2019 (2019-05-01), US , pages 759 - 772, XP055776481, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-18-0466
CAO SIHENG: "The Antitumor Effects of CAR-T Cells Targeting EpCAM Antigen on Colorectal Cancer", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, no. 10, 15 October 2018 (2018-10-15), CN , XP055926330, ISSN: 1674-0246
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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