Title:
T-CELLS SPECIFICALLY RECOGNIZING MINOR HISTOCOMPATIBILITY ANTIGEN(S) AND USES THEREOF FOR ELIMINATING TARGET CELLS
Document Type and Number:
WIPO Patent Application WO2002036750
Kind Code:
A3
Abstract:
This invention relates to T-cells that specifically recognize minor histocompatibility antigen(s), methods for selecting these T-cells and uses thereof for eliminating target cells, and more particularly for eliminating hematopoietic cancerous cells. The invention is based on 1) the priming of T-cells specifically reacting against a selected immunodominant ubiquitous MiHA that is expressed by target cells and by non-target cells; and also 2) the selection of a 100 % purified population of T-cells that specifically react against an immunodominant minor histocompatibility antigen which is ubiquitously expressed by the recipient's cells or selectively expressed by specific recipient's target cells only. The major advantage of the invention is that the T-cells used therein can be transferred from a donor to a compatible recipient without causing to the latter a graft-versus-host disease (GVHD) reaction.
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Inventors:
PERREAULT CLAUDE
Application Number:
PCT/CA2001/001477
Publication Date:
December 27, 2002
Filing Date:
October 19, 2001
Export Citation:
Assignee:
COMPATIGENE INC (CA)
International Classes:
A61K39/00; A61P35/00; C12N5/08; (IPC1-7): C12N5/08; C12N5/10; A61K39/00; A61P35/00
Foreign References:
| EP1020519A1 | 2000-07-19 |
Other References:
MUTIS TUNA ET AL: "Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens.", BLOOD, vol. 93, no. 7, 1 April 1999 (1999-04-01), pages 2336 - 2341, XP002210313, ISSN: 0006-4971
DIJK VAN A M C ET AL: "SELECTIVE DEPLETION OF MAJOR AND MINO HISTOCOMPATIBILITY ANTIGEN REACTIVE T CELLS: TOWARDS PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 1, no. 107, October 1999 (1999-10-01), pages 169 - 175, XP001074673, ISSN: 0007-1048
PERREAULT C ET AL: "Immunodominant minor histocompatibility antigens: the major ones", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 19, no. 2, 1 February 1998 (1998-02-01), pages 69 - 74, XP004107029, ISSN: 0167-5699
FONTAINE P ET AL: "Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease.", NATURE MEDICINE. UNITED STATES JUL 2001, vol. 7, no. 7, July 2001 (2001-07-01), pages 789 - 794, XP002210314, ISSN: 1078-8956
DIJK VAN A M C ET AL: "SELECTIVE DEPLETION OF MAJOR AND MINO HISTOCOMPATIBILITY ANTIGEN REACTIVE T CELLS: TOWARDS PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 1, no. 107, October 1999 (1999-10-01), pages 169 - 175, XP001074673, ISSN: 0007-1048
PERREAULT C ET AL: "Immunodominant minor histocompatibility antigens: the major ones", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 19, no. 2, 1 February 1998 (1998-02-01), pages 69 - 74, XP004107029, ISSN: 0167-5699
FONTAINE P ET AL: "Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease.", NATURE MEDICINE. UNITED STATES JUL 2001, vol. 7, no. 7, July 2001 (2001-07-01), pages 789 - 794, XP002210314, ISSN: 1078-8956
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