Title:
T-TYPE CALCIUM CHANNEL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/065532
Kind Code:
A1
Abstract:
Developed is a novel analgesic, the therapeutic targets of which are T-type calcium channels. The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound, or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product which contains this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is T-type calcium channel inhibitory activity. (In the formula, each of R1 and R2 independently represents H or -OH; R3 represents -OH; R4 represents -OH or -H; and R5 represents a linear or branched alkyl or cycloalkyl alkyl group having 1-10 carbon atoms, or a linear or branched alkenyl or cycloalkyl alkenyl group having 2-10 carbon atoms.)
Inventors:
KAWABATA ATSUFUMI (JP)
SEKIGUCHI FUMIKO (JP)
TSUBOTA MAHO (JP)
TOYOOKA NAOKI (JP)
NISHIKAWA HIROYUKI (JP)
SEKIGUCHI FUMIKO (JP)
TSUBOTA MAHO (JP)
TOYOOKA NAOKI (JP)
NISHIKAWA HIROYUKI (JP)
Application Number:
PCT/JP2018/035170
Publication Date:
April 04, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
UNIV KINKI (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
FUSO PHARMACEUTICAL IND (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
FUSO PHARMACEUTICAL IND (JP)
International Classes:
C07D311/32; A61K31/353; A61P25/00; A61P29/00; A61P43/00
Domestic Patent References:
| WO2014188980A1 | 2014-11-27 |
Other References:
YE, RIGUI ET AL., JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, 26 December 2016 (2016-12-26), pages 510 - 515, DOI: 10.1021/acs.jafc.66.4155
NGUYEN, HUY DU ET AL.: "Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, 19 July 2018 (2018-07-19), pages 4410 - 4427, XP085463633, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.07.023
NGUYEN, HUY DU ET AL.: "Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, 19 July 2018 (2018-07-19), pages 4410 - 4427, XP085463633, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.07.023
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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