Title:
TGF- alpha POLYPEPTIDES, FUNCTIONAL FRAGMENTS AND METHODS OF USE THEREFOR
Document Type and Number:
WIPO Patent Application WO2001012127
Kind Code:
A3
Abstract:
Disclosed are TGF- alpha polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
Inventors:
TWARDZIK DANIEL R
PERNET ANDRE
FELKER THOMAS S
PASKELL STEFAN
PERNET ANDRE
FELKER THOMAS S
PASKELL STEFAN
Application Number:
PCT/US2000/022882
Publication Date:
August 30, 2001
Filing Date:
August 17, 2000
Export Citation:
Assignee:
STEM CELL PHARMACEUTICALS INC (US)
International Classes:
C12N5/02; A61K38/22; A61P3/10; A61P31/18; A61P39/02; A61P43/00; C07K14/495; A61K38/00; C12R1/91; (IPC1-7): A61K38/00; C07K1/00
Domestic Patent References:
| WO1995024466A1 | 1995-09-14 | |||
| WO1996021676A1 | 1996-07-18 | |||
| WO1997025349A1 | 1997-07-17 |
Foreign References:
| US5690928A | 1997-11-25 |
Other References:
See also references of EP 1210102A4
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