THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS

Title:

THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005113560

Kind Code:

A3

Abstract:

This invention provides compounds of Formula II: wherein: R¹, R² and X are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection. The invention also provides processes for producing said compounds.

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Inventors:

BOSCHELLI DIANE HARRIS (US)
ZHANG NAN (US)
BARRIOS SOSA ANA CAROLINA (US)
DURUTLIC HARIS (US)
WU BIQI (US)

Application Number:

PCT/US2005/016150

Publication Date:

January 12, 2006

Filing Date:

May 10, 2005

Export Citation:

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Assignee:

WYETH CORP (US)
BOSCHELLI DIANE HARRIS (US)
ZHANG NAN (US)
BARRIOS SOSA ANA CAROLINA (US)
DURUTLIC HARIS (US)
WU BIQI (US)

International Classes:

C07D495/04; (IPC1-7): C07D495/04; A61K31/4365

Domestic Patent References:

WO2000066583A1	2000-11-09
WO2001072711A1	2001-10-04
WO2001047892A1	2001-07-05
WO2001094353A1	2001-12-13

Other References:

SHOWALTER, H. D. HOLLIS ET AL: "Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2- d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 26, 1999, pages 5464 - 5474, XP002352155
BOSCHELLI, DIANE H. ET AL: "Preparation of a series of benzothieno[3,2-b]pyridine-3- carbonitriles and benzofuro[3,2-b]pyridine-3-carbonitriles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 39, no. 4, 2002, pages 783 - 788, XP002352156
BOSCHELLI, DIANE H. ET AL: "Inhibition of Src kinase activity by 4-anilino-7-thienyl-3- quinolinecarbonitriles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 15, 2002, pages 2011 - 2014, XP002352157

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