Title:
THROMBIN OR FACTOR Xa INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002002519
Kind Code:
A3
Abstract:
This invention relates generally to heteroaryl-phenyl substituted compounds that are inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.
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Inventors:
PINTO DONALD J P
QUAN MIMI L
QUAN MIMI L
Application Number:
PCT/US2001/020962
Publication Date:
July 25, 2002
Filing Date:
June 29, 2001
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB PHARMA CO (US)
International Classes:
C07D207/09; C07D207/273; C07D213/64; C07D213/73; C07D241/18; C07D295/192; C07D295/26; C07D401/06; C07D471/04; C07D487/04; C07D517/04; C07D207/26; (IPC1-7): C07D487/04; A61K31/50
Domestic Patent References:
| WO1998028326A1 | 1998-07-02 | |||
| WO1997048706A1 | 1997-12-24 | |||
| WO1996019483A1 | 1996-06-27 | |||
| WO1998057937A2 | 1998-12-23 | |||
| WO1997023212A1 | 1997-07-03 |
Other References:
L.S. NARASIMHAN ET AL.: "Structural basis of the thrombin selectivity...", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 2000, WASHINGTON US, pages 361 - 368, XP002188952
ST-DENIS Y ET AL: "Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 22, 17 November 1998 (1998-11-17), pages 3193 - 3198, XP004143725, ISSN: 0960-894X
PLUMMER J S ET AL: "Potent and selective bicyclic lactam inhibitors of thrombin: part 2: P1 modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 23, 1 December 1998 (1998-12-01), pages 3409 - 3414, XP004143767, ISSN: 0960-894X
PLUMMER J S ET AL: "Potent and selective bicyclic lactam inhibitors of thrombin: part 3: P1' modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 6, 22 March 1999 (1999-03-22), pages 835 - 840, XP004160484, ISSN: 0960-894X
ST-DENIS Y ET AL: "Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 22, 17 November 1998 (1998-11-17), pages 3193 - 3198, XP004143725, ISSN: 0960-894X
PLUMMER J S ET AL: "Potent and selective bicyclic lactam inhibitors of thrombin: part 2: P1 modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 23, 1 December 1998 (1998-12-01), pages 3409 - 3414, XP004143767, ISSN: 0960-894X
PLUMMER J S ET AL: "Potent and selective bicyclic lactam inhibitors of thrombin: part 3: P1' modifications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 6, 22 March 1999 (1999-03-22), pages 835 - 840, XP004160484, ISSN: 0960-894X
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