Title:
TNF-$g(a) PRODUCTION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2001/092229
Kind Code:
A1
Abstract:
The invention provides TNF-$g(a) production inhibitors useful as remedies for autoimmune diseases such as rheumatoid arthritis. Novel compounds of the general formula [1] or salts thereof exhibit excellent TNF-a production inhibiting activities wherein A is -(NR?4¿)-, -(CR?5¿R?6¿)-, or -O-; B is alkylene or alkenylene; R?1¿, R?2¿, R?4¿, R?5¿, and R?6¿ are each hydrogen, alkyl, alkenyl, adamantylalkyl, or the like; R?3¿ is aryl or an unsaturated heterocyclic group; and X is oxygen or sulfur.
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| JPH0441425 | 5-LIPOXYGENASE INHIBITOR |
| JP2010059205 | SUBSTANCE INHIBITING PRODUCTION OF TNF- |
Inventors:
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
HORIUCHI MASATO (JP)
YAMAMOTO NORIYOSHI (JP)
ENOMOTO HIROSHI (JP)
INOUE HIROYUKI (JP)
SUHARA HIROSHI (JP)
HORIUCHI MASATO (JP)
YAMAMOTO NORIYOSHI (JP)
ENOMOTO HIROSHI (JP)
INOUE HIROYUKI (JP)
Application Number:
PCT/JP2001/004586
Publication Date:
December 06, 2001
Filing Date:
May 31, 2001
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
HORIUCHI MASATO (JP)
YAMAMOTO NORIYOSHI (JP)
ENOMOTO HIROSHI (JP)
INOUE HIROYUKI (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
HORIUCHI MASATO (JP)
YAMAMOTO NORIYOSHI (JP)
ENOMOTO HIROSHI (JP)
INOUE HIROYUKI (JP)
International Classes:
C07D233/61; A61K31/16; A61K31/18; A61K31/417; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/4525; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/513; A61K31/5377; A61P29/00; A61P37/00; A61P37/06; A61P43/00; C07C275/24; C07C311/39; C07D213/30; C07D213/32; C07D213/36; C07D213/38; C07D213/40; C07D213/55; C07D213/56; C07D213/59; C07D213/68; C07D213/74; C07D213/75; C07D215/12; C07D401/06; C07D401/12; C07D405/12; C07D409/12; C07D417/12; C07D487/04; (IPC1-7): C07D213/40; C07D213/68; C07D213/56; C07D213/30; C07D213/32; C07D213/84; C07D213/89; C07D233/61; C07D215/12; C07D401/06; C07D401/12; C07D409/12; C07D417/12; C07D405/12; A61K31/4409; A61K31/444; A61K31/4725; A61K31/5377; A61K31/4436; A61K31/4439; A61K31/443; A61K31/496; A61K31/4406; A61K31/4402; A61K31/47; A61K31/17; A61K31/4164; A61K31/506; A61K31/44; A61K31/16; A61K31/27; A61P43/00; A61P37/06; A61P29/00
Domestic Patent References:
| WO2000007985A1 | 2000-02-17 | |||
| WO1999050238A1 | 1999-10-07 | |||
| WO1997024355A1 | 1997-07-10 | |||
| WO1998027069A1 | 1998-06-25 |
Other References:
STARNES S.D., RUDKEVICH D.M., REBEK J. JR.: "A cavitand-porphyrin hybrid", ORG. LETT., vol. 2, no. 14, 2000, pages 1995 - 1998, XP002945963
See also references of EP 1302461A4
See also references of EP 1302461A4
Attorney, Agent or Firm:
Kishimoto, Einosuke c/o KISHIMOTO & CO. Inaba Building (3rd floor 13-18, Nishishinsaibashi 1-chom, Chuo-ku Osaka-shi Osaka, JP)
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