TAO KINASE MODULATORS AND METHODS OF USE

Title:

TAO KINASE MODULATORS AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO2005040355

Kind Code:

A3

Abstract:

The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Inventors:

BALY DEBORAH LYNN (US)
GALAN ADAM ANTONI (US)
IBRAHIM MOHAMED ABDULKADER (US)
JAEGER CHRISTOPHER (US)
KEARNEY PATRICK (US)
LEAHY JAMES WILLIAM (US)
LEWIS GARY LEE (US)
MCMILLAN KIRK (US)
NOGUCHI ROBIN TAMMIE (US)
NUSS JOHN M (US)
PARKS JASON JEVIOUS (US)
SCHNEPP KEVIN LUKE (US)
SHI XIAN (US)
WILLIAMS MATTHEW ALAN (US)
XU WEI (US)
ZHENG WENTAO (US)

Application Number:

PCT/US2004/035469

Publication Date:

August 04, 2005

Filing Date:

October 22, 2004

Export Citation:

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Assignee:

EXELIXIS INC (US)
BALY DEBORAH LYNN (US)
GALAN ADAM ANTONI (US)
IBRAHIM MOHAMED ABDULKADER (US)
JAEGER CHRISTOPHER (US)
KEARNEY PATRICK (US)
LEAHY JAMES WILLIAM (US)
LEWIS GARY LEE (US)
MCMILLAN KIRK (US)
NOGUCHI ROBIN TAMMIE (US)
NUSS JOHN M (US)
PARKS JASON JEVIOUS (US)
SCHNEPP KEVIN LUKE (US)
SHI XIAN (US)
WILLIAMS MATTHEW ALAN (US)
XU WEI (US)
ZHENG WENTAO (US)

International Classes:

A61K31/16; A61K31/17; C07C233/64; C07C237/22; C07C275/06; C07C275/16; C07C275/28; C07C275/34; C07D207/16; C07D209/20; C07D209/44; C07D213/56; C07D213/75; C07D215/48; C07D215/54; C07D217/06; C07D217/22; C07D233/58; C07D263/32; C07D277/82; C07D295/155; C07D295/185; C07D319/20; C07D401/04; C07D405/12; C07D471/04; C07D495/04; C07D513/04; C12N; (IPC1-7): C07C233/64; C07C275/06; C07C275/28; A61K31/16; A61K31/17

Foreign References:

US5877218A	1999-03-02
US20030191279A1	2003-10-09

Other References: