Title:
TARGETED EXOSOME BASED ON RBD REGION OF SARS-COV-2 S PROTEIN AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/077968
Kind Code:
A1
Abstract:
Provided are a targeted exosome based on an RBD region of an SARS-CoV-2 S protein and a preparation method therefor. An RBD-VSVG fusion protein is expressed on the targeted exosome, and the RBD-VSVG fusion protein is obtained by replacing an extracellular region of VSVG with the RBD of the SARS-CoV-2 S protein. SARS-CoV-2 siRNA is wrapped by the targeted exosome, thus specifically inhibiting virus replication in tissues and organs.
Inventors:
XIONG SIDONG (CN)
FU YUXUAN (CN)
FU YUXUAN (CN)
Application Number:
PCT/CN2021/105245
Publication Date:
April 21, 2022
Filing Date:
July 08, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K45/00; C12N5/10; A61K47/42; A61K47/46; A61P31/14; C12N15/85
Foreign References:
| CN112226413A | 2021-01-15 | |||
| CN111647557A | 2020-09-11 |
Other References:
FU, YX ET AL.: "Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection", JOURNAL OF CONTROLLED RELEASE, vol. 335, 3 June 2021 (2021-06-03), XP086685232, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2021.05.049
LUO XIAOMIN, YAN CEN, FENG YINGMEI: "Advances and Prospects in COVID-19", BEIJING MEDICAL JOURNAL, vol. 42, no. 10, 10 October 2020 (2020-10-10), pages 911 - 916, XP055922627, ISSN: 0253-9713, DOI: 10.15932/j.0253-9713.2020.10.001
PINKY ET AL.: "Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19", STEM CELL REVIEWS AND REPORTS, vol. 17, no. 1, 13 July 2020 (2020-07-13), XP037374747, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10002-z
LUO XIAOMIN, YAN CEN, FENG YINGMEI: "Advances and Prospects in COVID-19", BEIJING MEDICAL JOURNAL, vol. 42, no. 10, 10 October 2020 (2020-10-10), pages 911 - 916, XP055922627, ISSN: 0253-9713, DOI: 10.15932/j.0253-9713.2020.10.001
PINKY ET AL.: "Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19", STEM CELL REVIEWS AND REPORTS, vol. 17, no. 1, 13 July 2020 (2020-07-13), XP037374747, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10002-z
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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