Title:
TARGETED LIPID PARTICLES
Document Type and Number:
WIPO Patent Application WO2001012154
Kind Code:
A3
Abstract:
Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
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Inventors:
BAKER TERENCE SEWARD (GB)
WEIR ANDREW NEIL CHARLES (GB)
CATTERALL CATHERINE FIONA (GB)
EATON MICHAEL ANTHONY WILLIAM (GB)
NORMAN TIMOTHY JOHN (GB)
PARKER DAVID (GB)
WEIR ANDREW NEIL CHARLES (GB)
CATTERALL CATHERINE FIONA (GB)
EATON MICHAEL ANTHONY WILLIAM (GB)
NORMAN TIMOTHY JOHN (GB)
PARKER DAVID (GB)
Application Number:
PCT/GB2000/003170
Publication Date:
October 11, 2001
Filing Date:
August 16, 2000
Export Citation:
Assignee:
CELLTECH CHIROSCIENCE LTD (GB)
BAKER TERENCE S (GB)
WEIR ANDREW NEIL CHARLES (GB)
CATTERALL CATHERINE FIONA (GB)
EATON MICHAEL ANTHONY WILLIAM (GB)
NORMAN TIMOTHY JOHN (GB)
PARKER DAVID (GB)
BAKER TERENCE S (GB)
WEIR ANDREW NEIL CHARLES (GB)
CATTERALL CATHERINE FIONA (GB)
EATON MICHAEL ANTHONY WILLIAM (GB)
NORMAN TIMOTHY JOHN (GB)
PARKER DAVID (GB)
International Classes:
A61K47/16; A61K9/14; A61K47/42; A61K47/48; A61K48/00; C07C229/08; C07C233/36; C07C237/10; C07C271/20; C07C271/22; C12N15/87; (IPC1-7): A61K47/48
Domestic Patent References:
| WO1999052858A2 | 1999-10-21 | |||
| WO2000064858A1 | 2000-11-02 |
Other References:
FUHRHOP J -H ET AL: "BOLAAMPHIPHILES WITH MANNOSE- AND TETRAALKYLAMMONIUM HEAD GROUPS ASCOATINGS FOR NUCLEIC ACIDS AND POSSIBLE REAGENTS FOR TRANSFECTIONS", CHEMISTRY AND PHYSICS OF LIPIDS,IR,LIMERICK, vol. 43, 1 April 1987 (1987-04-01), pages 193 - 213, XP000562618, ISSN: 0009-3084
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