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Title:
TARGETED PROTEASE DEGRADATION PLATFORM
Document Type and Number:
WIPO Patent Application WO/2020/073930
Kind Code:
A1
Abstract:
Disclosed is a targeted protease degradation platform (TED), which in particular is a conjugate of target molecule-linker-E3 ligase ligand as shown in the structure of A-L1-B (formula I), wherein the A is the monovalent group of the target molecule, the B is the monovalent group of the E3 ligase ligand, the L1 is the linker linking A and B, and L1 is as shown in -X-L2-Y- (formula II).

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Inventors:
CAO SHELDON (CN)
WANG XIAOLEI (CN)
HUANG CHAORAN (CN)
Application Number:
PCT/CN2019/110225
Publication Date:
April 16, 2020
Filing Date:
October 09, 2019
Export Citation:
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Assignee:
EUBULUS BIOTHERAPEUTICS INC (CN)
International Classes:
A61K47/66; A61P35/00
Domestic Patent References:
WO2018119441A12018-06-28
WO2018119441A12018-06-28
WO2017201449A12017-11-23
WO2018102067A22018-06-07
WO2018102067A22018-06-07
WO2018226542A12018-12-13
WO2018226542A12018-12-13
WO2017185034A12017-10-26
WO2017185034A12017-10-26
WO2017176957A12017-10-12
WO2017176957A12017-10-12
WO2017176958A12017-10-12
Foreign References:
CN108136044A2018-06-08
CN108136044A2018-06-08
CN106458993A2017-02-22
CN106458993A2017-02-22
Other References:
BERGE, S.M. ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
KABAT ET AL., NIH PUBL, vol. I, no. 91-3242, 1991, pages 647 - 669
See also references of EP 3865152A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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