Title:
TARGETING SUCNR1 TO REDUCE NEUROINFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2023/183776
Kind Code:
A3
Abstract:
The present disclose provides methods for treating neuroinflammation. Compositions having therapeutic agents targeted to interfering with succinate/succinate receptor signaling are administered to reduce or ameliorate neuroinflammation. The neuroinflammation may be associated with, caused by, or result from diseases/pathologies/disorders associated with the central nervous system.
Inventors:
LI XIN (US)
SAXENA DEEPAK (US)
GUO YUQI (US)
SAXENA DEEPAK (US)
GUO YUQI (US)
Application Number:
PCT/US2023/064718
Publication Date:
November 02, 2023
Filing Date:
March 20, 2023
Export Citation:
Assignee:
UNIV NEW YORK (US)
International Classes:
A61P25/00; A61K31/4375; A61P29/00; C07D471/04
Foreign References:
| US20200383902A1 | 2020-12-10 |
Other References:
PERUZZOTTI-JAMETTI LUCA, WILLIS CORY M., HAMEL REGAN, KRZAK GRZEGORZ, PLUCHINO STEFANO: "Metabolic Control of Smoldering Neuroinflammation", FRONTIERS IN IMMUNOLOGY, vol. 12, XP093106007, DOI: 10.3389/fimmu.2021.705920
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "compound 7e [PubMed ID 21571530]", XP093105952, retrieved from PUBCHEM
MONFARED ROUDABEH VAKIL, ALHASSEN WEDAD, TRUONG TRI MINH, GONZALES MICHAEL ANGELO MAGLALANG, VACHIRAKORNTONG VINCENT, CHEN SIWEI, : "Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions", CELLS, vol. 10, no. 11, pages 2967, XP093106011, DOI: 10.3390/cells10112967
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "compound 7e [PubMed ID 21571530]", XP093105952, retrieved from PUBCHEM
MONFARED ROUDABEH VAKIL, ALHASSEN WEDAD, TRUONG TRI MINH, GONZALES MICHAEL ANGELO MAGLALANG, VACHIRAKORNTONG VINCENT, CHEN SIWEI, : "Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions", CELLS, vol. 10, no. 11, pages 2967, XP093106011, DOI: 10.3390/cells10112967
Attorney, Agent or Firm:
DIMAIO, John et al. (US)
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