Title:
TARGETS FOR HERBICIDES AND TRANSGENIC PLANTS RESISTANT TO SAID HERBICIDES
Document Type and Number:
WIPO Patent Application WO2002046441
Kind Code:
A3
Abstract:
The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.
Inventors:
MATRINGE MICHEL (FR)
RIPPERT PASCAL (FR)
RIPPERT PASCAL (FR)
Application Number:
PCT/FR2001/003832
Publication Date:
February 20, 2003
Filing Date:
December 05, 2001
Export Citation:
Assignee:
AVENTIS CROPSCIENCE SA (FR)
MATRINGE MICHEL (FR)
RIPPERT PASCAL (FR)
MATRINGE MICHEL (FR)
RIPPERT PASCAL (FR)
International Classes:
C07K14/415; C12N1/19; C12N1/21; C12N9/02; C12N9/10; C12N15/53; C12N15/55; C12N15/82; (IPC1-7): C12N15/82; A01H5/00; C07K14/415; C12N1/19; C12N1/21; C12N9/02; C12N9/10; C12N15/53; C12N15/55
Foreign References:
| US5187071A | 1993-02-16 |
Other References:
DATABASE EMBL [online] 11 June 1999 (1999-06-11), KANEKO T ET AL.: "Arabidopsis thaliana genomic DNA, gene_id:MGG23.1, contains similarity to chorismate mutase-T and prephenate dehydrogenase", XP002173387, Database accession no. AB028613
DATABASE EMBL [online] 7 April 2000 (2000-04-07), LIU S X ET AL.: "Arabidopsis thaliana clone F7H2, contains similarity to embryonic abundant protein (EMB20) from Picea glauca", XP002173388, Database accession no. AC034256
DATABASE EMBL [online] 6 June 1996 (1996-06-06), DONG J-Z AND DUNSTAN D I: "Picea glauca embryo abundance protein (EMB20)", XP002173389, Database accession no. L47749
DATABASE EMBL [online] 31 October 1996 (1996-10-31), KANEKO T EL AL.: "Synechocystic sp. gene tyrA, prephenate dehydrogenase", XP002173390, Database accession no. D90910
RUBIN J L ET AL: "ENZYMOLOGICAL BASIS FOR HERBICIDAL ACTION OF GLYPHOSATE", PLANT PHYSIOLOGY (BETHESDA), vol. 70, no. 3, 1982, pages 833 - 839, XP001010626, ISSN: 0032-0889
ROISCH U ET AL: "MECHANISM OF ACTION OF THE HERBICIDE N PHOSPHONOMETHYL GLYCINE ITS EFFECT ON GROWTH AND ENZYMES OF AROMATIC AMINO-ACID BIOSYNTHESIS IN ESCHERICHIA-COLI", HOPPE-SEYLER'S ZEITSCHRIFT FUER PHYSIOLOGISCHE CHEMIE, vol. 361, no. 7, 1980, pages 1049 - 1058, XP001010625, ISSN: 0018-4888
CONNELLY J A ET AL: "TYROSINE BIOSYNTHESIS IN SORGHUM-BICOLOR ISOLATION AND REGULATORY PROPERTIES OF AROGENATE DEHYDROGENASE", ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C BIOSCIENCES, vol. 41, no. 1-2, 1986, pages 69 - 78, XP001010607, ISSN: 0341-0382
BYNG G ET AL: "ENZYMOLOGY OF L TYROSINE BIOSYNTHESIS IN CORN ZEA-MAYS", PHYTOCHEMISTRY (OXFORD), vol. 20, no. 6, 1981, pages 1289 - 1292, XP001010619, ISSN: 0031-9422
GAINES C G ET AL: "L TYROSINE REGULATION AND BIOSYNTHESIS VIA AROGENATE DEHYDROGENASE IN SUSPENSION CULTURED CELLS OF NICOTIANA-SILVESTRIS", PLANTA (HEIDELBERG), vol. 156, no. 3, 1982, pages 233 - 240, XP001010647, ISSN: 0032-0935
DATABASE EMBL [online] 7 April 2000 (2000-04-07), LIU S X ET AL.: "Arabidopsis thaliana clone F7H2, contains similarity to embryonic abundant protein (EMB20) from Picea glauca", XP002173388, Database accession no. AC034256
DATABASE EMBL [online] 6 June 1996 (1996-06-06), DONG J-Z AND DUNSTAN D I: "Picea glauca embryo abundance protein (EMB20)", XP002173389, Database accession no. L47749
DATABASE EMBL [online] 31 October 1996 (1996-10-31), KANEKO T EL AL.: "Synechocystic sp. gene tyrA, prephenate dehydrogenase", XP002173390, Database accession no. D90910
RUBIN J L ET AL: "ENZYMOLOGICAL BASIS FOR HERBICIDAL ACTION OF GLYPHOSATE", PLANT PHYSIOLOGY (BETHESDA), vol. 70, no. 3, 1982, pages 833 - 839, XP001010626, ISSN: 0032-0889
ROISCH U ET AL: "MECHANISM OF ACTION OF THE HERBICIDE N PHOSPHONOMETHYL GLYCINE ITS EFFECT ON GROWTH AND ENZYMES OF AROMATIC AMINO-ACID BIOSYNTHESIS IN ESCHERICHIA-COLI", HOPPE-SEYLER'S ZEITSCHRIFT FUER PHYSIOLOGISCHE CHEMIE, vol. 361, no. 7, 1980, pages 1049 - 1058, XP001010625, ISSN: 0018-4888
CONNELLY J A ET AL: "TYROSINE BIOSYNTHESIS IN SORGHUM-BICOLOR ISOLATION AND REGULATORY PROPERTIES OF AROGENATE DEHYDROGENASE", ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C BIOSCIENCES, vol. 41, no. 1-2, 1986, pages 69 - 78, XP001010607, ISSN: 0341-0382
BYNG G ET AL: "ENZYMOLOGY OF L TYROSINE BIOSYNTHESIS IN CORN ZEA-MAYS", PHYTOCHEMISTRY (OXFORD), vol. 20, no. 6, 1981, pages 1289 - 1292, XP001010619, ISSN: 0031-9422
GAINES C G ET AL: "L TYROSINE REGULATION AND BIOSYNTHESIS VIA AROGENATE DEHYDROGENASE IN SUSPENSION CULTURED CELLS OF NICOTIANA-SILVESTRIS", PLANTA (HEIDELBERG), vol. 156, no. 3, 1982, pages 233 - 240, XP001010647, ISSN: 0032-0935
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