TAXANE DERIVATIVES AND DRUGS CONTAINING THE SAME

Title:

TAXANE DERIVATIVES AND DRUGS CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1998/002426

Kind Code:

A1

Abstract:

Taxane derivatives of general formula (1) and drugs containing the same wherein at least either of X and Y is -CO-A-B (wherein A is a single bond, alkylenecarbonyl or the like, and B is optionally substituted piperidono or the like); and the other thereof is t-butoxycarbonyl or the like; and Z is H or triethylsilyl. These compounds exhibit a high solubility in water and are excellent in antitumor activity.

Inventors:

SHIMIZU HIDEAKI (JP)
ABE ATSUHIRO (JP)
YAEGASHI TAKASHI (JP)
SAWADA SEIGO (JP)
NAGATA HIROSHI (JP)

Application Number:

PCT/JP1997/002431

Publication Date:

January 22, 1998

Filing Date:

July 14, 1997

Export Citation:

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Assignee:

YAKULT HONSHA KK (JP)
SHIMIZU HIDEAKI (JP)
ABE ATSUHIRO (JP)
YAEGASHI TAKASHI (JP)
SAWADA SEIGO (JP)
NAGATA HIROSHI (JP)

International Classes:

C07D305/14; C07D405/12; C07D413/12; C07D413/14; (IPC1-7): C07D305/14; C07D413/12; A61K31/335

Foreign References:

JPH03505725A	1991-12-12
JPH07503477A	1995-04-13

Other References: