Title:
TAXANES COMPOUNDS, PREPARATION METHOD THEREFOR, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/074605
Kind Code:
A1
Abstract:
The present invention provides taxanes compounds with a formula (I) or formula (II) structure, a method for preparing the compounds, and the compound, and uses of medicinal salts thereof and solvates used as compositions of active ingredients in the preparation of oral antitumor medicaments. In formula (I), R1 is -COR6, -COOR6, or -CONR7aR7b; R2 is C1-C6 alkyl, C1-C6 alkenyl, substitution hydrocarbyl, heterocyclic radical, aromatic group or substitute aromatic nucleus; R3 is -OR6, -OCOOR6, -OCOSR6, or -OCONR7aR7b; R4 is -OR6, -OCOOR6, -OCOSR6, -OCONR7aR7b, or H; R6 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, substitution hydrocarbyl, aromatic group or heterocyclic radical; R7a, R7b is hydrogen, hydrocarbyl, substitution hydrocarbyl or heterocyclic radical. In formula (II), R1 is -COR6, or -COOR6; R2 is aromatic group; R3 is -OR6; and R6 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, substitution hydrocarbyl, aromatic group or heterocyclic radical.
Inventors:
ZHOU WEI (CN)
JING YUNRONG (CN)
WANG YONGFENG (CN)
WANG GUOCHENG (CN)
JING YUNRONG (CN)
WANG YONGFENG (CN)
WANG GUOCHENG (CN)
Application Number:
PCT/CN2014/091908
Publication Date:
May 28, 2015
Filing Date:
November 21, 2014
Export Citation:
Assignee:
TASLY HOLDING GROUP CO LTD (CN)
International Classes:
A61K31/337; C07D305/14; A61K31/4427; A61P35/00; A61P35/02; C07D405/12
Domestic Patent References:
| WO1993002065A1 | 1993-02-04 |
Foreign References:
| CN1179776A | 1998-04-22 | |||
| CN1210525A | 1999-03-10 | |||
| CN1094041A | 1994-10-26 | |||
| CN1087905A | 1994-06-15 | |||
| CN1709864A | 2005-12-21 |
Other References:
JING, YUNRONG ET AL.: "The Synthesis of Novel Taxoids for Oral Administration", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, 27 November 2013 (2013-11-27), pages 194 - 203, XP055345462
TIJE AJ ET AL., CLIN PHARMACOKINET, vol. 42, 2003, pages 655 - 685
H. GELDERBLOM ET AL., EUR. J. CANCER, vol. 37, no. 13, 2001, pages 1590 - 1598
VAN ZUYLEN L ET AL., INVEST NEW DRUGS, vol. 19, 2001, pages 125 - 141
R. B. WEISS ET AL., J. CLIN. ONCOL., vol. 8, no. 7, 1990, pages 1263 - 1268
TIJE AJ ET AL., CLIN PHARMACOKINET, vol. 42, 2003, pages 655 - 685
H. GELDERBLOM ET AL., EUR. J. CANCER, vol. 37, no. 13, 2001, pages 1590 - 1598
VAN ZUYLEN L ET AL., INVEST NEW DRUGS, vol. 19, 2001, pages 125 - 141
R. B. WEISS ET AL., J. CLIN. ONCOL., vol. 8, no. 7, 1990, pages 1263 - 1268
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
北京信慧永光知识产权代理有限责任公司 (CN)
北京信慧永光知识产权代理有限责任公司 (CN)
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