Title:
TBPB PROTEINS IN ATTENUATED ORAL LIVE VACCINES
Document Type and Number:
WIPO Patent Application WO2008058116
Kind Code:
B1
Abstract:
A procedure for obtaining the expression of a membrane antigen of a pathogen against which an live oral vaccine development is desirable on the surface of a negative Gram bacteria to which virulence is attenuated, or another bacteria or other Gram negative or positive bacteria with probiotic features which are compatible with the proposed expression system and that can be used as a live oral vaccine, wherein a plasmid is constructed and obtained based on the structure of pET family plasmids, with tbpB gene incorporated under the control of T7 promoter or another equivalent one, with the addition of a metabolic marker in the plasmid vector, previously cloned with its own promoter, inactivating, at the same time, the antibiotic resistance. In addition, recombinant microorganism such as an attenuated vaccine strain against group B meningitis with immunizing and protective properties against infection by Neisseria meningitides.
Inventors:
ESPARZA ALEJANDRO VENEGAS (CL)
Application Number:
PCT/US2007/083750
Publication Date:
September 04, 2008
Filing Date:
November 06, 2007
Export Citation:
Assignee:
UNIV PONTIFICIA CATOLICA CHILE (CL)
LEIVA ALVARO RODRIGO VENEGAS (CL)
ESPARZA ALEJANDRO VENEGAS (CL)
LEIVA ALVARO RODRIGO VENEGAS (CL)
ESPARZA ALEJANDRO VENEGAS (CL)
International Classes:
A61K39/116; A01N65/00; A61K39/095
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