TECHNETIUM CARBON MICROSPHERE INJECTION, PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

TECHNETIUM CARBON MICROSPHERE INJECTION, PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/238529

Kind Code:

A1

Abstract:

Disclosed is a technetium [99mTc] carbon microsphere injection. The injection comprises carbon microspheres and radionuclide technetium [99mTc] adsorbed in the carbon microspheres. Every 1 ml of the injection contains 0.5-200 mg of carbon microspheres, and contains radioactive [99mTc] technetium having an activity of 0.1-100 mCi. The preparation method comprises the step of mixing a sterile pertechnetate (99mTcO4 -) solution with carbon microsphere dry powder or a carbon microsphere suspension. The injection is high in labeling rate, low in release rate, and simple in preparation method, overcomes the major problem that short half-life radiopharmaceuticals are prone to decay and lose efficacy or a large number of radionuclides are lost, and provides a brand-new imaging agent for SPECT diagnosis.

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Inventors:

ZHAO XIAOSHENG (CN)
GE QIANG (CN)
LI ZHUOMING (CN)
ZHANG JUN (CN)
LU JING (CN)
ZHANG CHIXIANG (CN)
LI MAOLIANG (CN)
MULLETT WAYNE (CA)
WANG SUSAN (US)
CAI JIMING (CN)

Application Number:

PCT/CN2021/089195

Publication Date:

December 02, 2021

Filing Date:

April 23, 2021

Export Citation:

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Assignee:

CHENGDU NEW RADIOMEDICINE TECH CO LTD (CN)

International Classes:

A61K51/12; A61K51/02; A61K103/10

Foreign References:

CN101198360A	2008-06-11
CN107224592A	2017-10-03
CN1331081A	2002-01-16
CN103370063A	2013-10-23
CN101321542A	2008-12-10

Other References:

GE HAOBO, RISS PATRICK J., MIRABELLO VINCENZO, CALATAYUD DAVID G., FLOWER STEPHEN E., ARROWSMITH RORY L., FRYER TIM D., HONG YOUNG: "Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo", CHEM, vol. 3, no. 3, 14 September 2017 (2017-09-14), pages 1 - 24, XP055871689, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2017.06.013

Attorney, Agent or Firm:

CHENGDU CENTRAL ASIA PATENT AGENCY CO., LTD (CN)

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