Title:
TEMPERATURE-RESPONSIVE DRUG/POLYMER COMPOUND AND APPLICATION OF COMPOUND TO DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2021/020342
Kind Code:
A1
Abstract:
The present invention has been made to solve the problem and the main purpose thereof is to provide a method for efficiently delivering a drug to the lungs. In the present invention, by using a temperature-responsive drug/polymer compound, aggregates of the compound can be formed in an aqueous medium in a temperature-dependent manner. The aggregates can be absorbed transpulmonarily and can be suitably retained in lung tissues, thereby achieving efficient delivery of the drug to the lungs.
Inventors:
MIYATA KANJIRO (JP)
KIM BEOB SOO (JP)
OSAWA SHIGEHITO (JP)
NAITO MITSURU (JP)
CHAYA HIROYUKI (JP)
KIM BEOB SOO (JP)
OSAWA SHIGEHITO (JP)
NAITO MITSURU (JP)
CHAYA HIROYUKI (JP)
Application Number:
PCT/JP2020/028698
Publication Date:
February 04, 2021
Filing Date:
July 27, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K9/107; A61K31/7088; A61K31/7105; A61K38/00; A61K47/59
Foreign References:
| JP2019038787A | 2019-03-14 |
Other References:
TANG ZHONGLAN, TAKARADA TOHRU, MAEDA MIZUO: "Non-Cross-Linking Aggregation of DNA-Carrying Polymer Micelles Triggered by Duplex Formation", LANGMUIR, vol. 34, no. 49, 11 December 2018 (2018-12-11), pages 14899 - 14910, XP055788035
ITAKA KEIJI ET AL.: "Gene transfer into the lung by nanocarriers that have both functionality and inflammation control", PREPRINTS OF THE 33RD ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, 31 December 2011 (2011-12-31), pages 215
NAKAYAMA MASAMICHI, OKANO TERUO: "Intelligent biomaterials and DDS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 210, no. 9, 28 August 2004 (2004-08-28), pages 721 - 725
ITAKA KEIJI ET AL.: "Gene transfer into the lung by nanocarriers that have both functionality and inflammation control", PREPRINTS OF THE 33RD ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, 31 December 2011 (2011-12-31), pages 215
NAKAYAMA MASAMICHI, OKANO TERUO: "Intelligent biomaterials and DDS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 210, no. 9, 28 August 2004 (2004-08-28), pages 721 - 725
Attorney, Agent or Firm:
MOMII, Takafumi (JP)
Download PDF:
Previous Patent: SIGNAL TRANSMITTING SYSTEM AND SIGNAL TRANSMITTING METHOD
Next Patent: HEATING COOKER
Next Patent: HEATING COOKER