Title:
TERLIPRESSIN-OCTADECANEDIOIC ACID CONJUGATE FOR VASOCONSTRICTIVE THERAPY
Document Type and Number:
WIPO Patent Application WO/2021/127234
Kind Code:
A3
Abstract:
In an aspect, disclosed herein is a compound characterized by formula (FX1): A1—X1—X2—A2 (FX1); wherein: A1 is a carboxylic acid group, a carboxylate anion, or a carboxylate ester; X1 is a substituted or unsubstituted and saturated or unsaturated C1-C50 aliphatic group; X2 is a linker group selected from the group consisting of a direct bond, an organic group, -0-, -S-, -S(=O)-, -S(=O)2-, -S-S-, -N=, =N-, -N(H)-, -N=N-N(H)-, -N(H)-N=N-, -N(OH)-, -N(=O)-, and any combination thereof; and A2 is a peptide, the peptide being terlipressin or a substituted or unsubstituted derivative, a substituted or unsubstituted natural or synthetic analogue, a substituted or unsubstituted variant, a substituted or unsubstituted isomer, or a substituted or unsubstituted fragment of terlipressin.
More Like This:
| WO/2003/079978 | PROTEASE ACTIVITY OF THROMBIN INHIBITS ANGIOGENESIS |
| WO/2015/138473 | AUTOASSEMBLING PEPTIDES FOR THE TREATMENT OF PULMONARY LEAKAGE |
| WO/1999/003491 | NEW USE OF NOCICEPTIN |
Inventors:
BERGER OR (US)
CHOI WONMIN (US)
GIANNESCHI NATHAN C (US)
BATLLE DANIEL (US)
CHOI WONMIN (US)
GIANNESCHI NATHAN C (US)
BATLLE DANIEL (US)
Application Number:
PCT/US2020/065692
Publication Date:
July 22, 2021
Filing Date:
December 17, 2020
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
International Classes:
A61K38/10; C07K2/00; C07K7/06
Foreign References:
| US20090088387A1 | 2009-04-02 | |||
| US20190240284A1 | 2019-08-08 | |||
| US20060276626A1 | 2006-12-07 | |||
| US20110171312A1 | 2011-07-14 | |||
| US7030082B2 | 2006-04-18 |
Attorney, Agent or Firm:
CHERNOMORDIK, Boris D. et al. (US)
Download PDF: