Title:
TERPYRIDINE IRON/RUTHENIUM COMPLEX CONTAINING NITROGEN MUSTARD, SYNTHESIS METHOD AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2022/170893
Kind Code:
A1
Abstract:
A terpyridine iron/ruthenium complex containing nitrogen mustard, a synthesis method and an application. The structural formula of the terpyridine iron/ruthenium complex containing nitrogen mustard is as shown below, wherein M is one of Fe or Ru. In vitro anti-tumor activity experiments show that the complex can effectively inhibit growth, migration, crawling and cloning of tumor cells, such that the tumor cell cycle is blocked in G1 period, and apoptosis is induced.
Inventors:
LIANG YUANWEI (CN)
SU WEIMING (CN)
WANG SIQI (CN)
HUANG WEITING (CN)
CHEN JIANPING (CN)
ZHANG KAIEN (CN)
SU WEIMING (CN)
WANG SIQI (CN)
HUANG WEITING (CN)
CHEN JIANPING (CN)
ZHANG KAIEN (CN)
Application Number:
PCT/CN2022/070201
Publication Date:
August 18, 2022
Filing Date:
January 05, 2022
Export Citation:
Assignee:
UNIV GUANGDONG OCEAN (CN)
International Classes:
C07F15/00; A61P35/00; C07F15/02
Foreign References:
| CN112940046A | 2021-06-11 | |||
| CN111039853A | 2020-04-21 | |||
| CN110997600A | 2020-04-10 |
Other References:
YANG XINDA, ZHANG DUOTENG, LI JIE, JI WENHUI, YANG NAIDI, GU SHUNXIN, WU QIONG, JIANG QIN, SHI PENGFEI, LI LIN: ")-terpyridine complex for two-photon photodynamic therapy", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 56, no. 63, 6 August 2020 (2020-08-06), UK , pages 9032 - 9035, XP055959237, ISSN: 1359-7345, DOI: 10.1039/D0CC02051F
ZOU BI-QUN, WANG SHU-LONG, QIN QI-PIN, BAI YU-XIA, TAN MING-XIONG: "Synthesis, Characterization, and Cytotoxicity of the Cobalt (III) Complex with N , N -Diethyl-4-(2,2′:6′,2′′-terpyridin-4′-yl)aniline", CHEMISTRY & BIODIVERSITY, HELVETICA CHIMICA ACTA, ZUERICH, CH, vol. 15, no. 10, 1 October 2018 (2018-10-01), CH , pages e1800215, XP055959240, ISSN: 1612-1872, DOI: 10.1002/cbdv.201800215
ZOU BI-QUN, WANG SHU-LONG, QIN QI-PIN, BAI YU-XIA, TAN MING-XIONG: "Synthesis, Characterization, and Cytotoxicity of the Cobalt (III) Complex with N , N -Diethyl-4-(2,2′:6′,2′′-terpyridin-4′-yl)aniline", CHEMISTRY & BIODIVERSITY, HELVETICA CHIMICA ACTA, ZUERICH, CH, vol. 15, no. 10, 1 October 2018 (2018-10-01), CH , pages e1800215, XP055959240, ISSN: 1612-1872, DOI: 10.1002/cbdv.201800215
Attorney, Agent or Firm:
BEIJING DONGFANG SHENGFAN IP AGENT FIRM GP (CN)
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