Title:
TERTIARY AMIDE DERIVATIVE SUBSTITUTED BY QUATERNARY CARBON
Document Type and Number:
WIPO Patent Application WO/2024/034652
Kind Code:
A1
Abstract:
The present disclosure provides: a tertiary amide derivative substituted by quaternary carbon that is useful as a medicine and a pharmaceutically acceptable salt of the tertiary amide derivative; a pharmaceutical composition comprising these components; and a therapeutic or prophylactic agent for a disease condition in which CBP/P300 is involved, the therapeutic or prophylactic agent comprising the composition. More specifically, the present disclosure provides a compound represented by formula (1) [wherein A represents CR6aR6b, C=O, C=CH2 or S(=O)2; B represents formula (B-1); the ring Q represents an optionally substituted 6- to 10-membered aromatic hydrocarbon ring or an optionally substituted 5- to 10-membered aromatic heterocyclic ring; Z represents -O-, -N(R7a)-, an optionally substituted 6- to 10-membered bivalent aromatic ring group, an optionally substituted 5- to 10-membered bivalent aromatic heterocyclic ring group, an optionally substituted 4- to 10-membered bivalent non-arylheterocyclic ring group; and R1, R2a and R2b, R3, R4, and R5 are as described in the description] or a pharmaceutically acceptable salt thereof.
Inventors:
UESUGI SHUNICHIRO (JP)
KAMIOKA SEIJI (JP)
BAN HITOSHI (JP)
IMAZAKI YUSUKE (JP)
KAMEI YUSUKE (JP)
OGIWARA HIDEAKI (JP)
SASAKI MARIKO (JP)
KAMIOKA SEIJI (JP)
BAN HITOSHI (JP)
IMAZAKI YUSUKE (JP)
KAMEI YUSUKE (JP)
OGIWARA HIDEAKI (JP)
SASAKI MARIKO (JP)
Application Number:
PCT/JP2023/029183
Publication Date:
February 15, 2024
Filing Date:
August 09, 2023
Export Citation:
Assignee:
SUMITOMO PHARMA CO LTD (JP)
NAT CANCER CT (JP)
NAT CANCER CT (JP)
International Classes:
A61K31/4184; C07D401/14; A61K31/4188; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61K45/00; A61P1/16; A61P3/00; A61P9/00; A61P35/00; A61P43/00; C07D403/04; C07D403/14; C07D405/12; C07D405/14; C07D495/10; C12N9/10; C12N9/99
Foreign References:
| US20160235716A1 | 2016-08-18 | |||
| JP2022510874A | 2022-01-28 | |||
| JP2021522317A | 2021-08-30 | |||
| JP2022512900A | 2022-02-07 |
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
Download PDF:
Previous Patent: LID, LIDDED CONTAINER, AND COMBINATION OF LID AND CONTAINER
Next Patent: LID, CUP CONTAINER, PACKAGE, AND PACKAGE WITH CONTENT THEREIN
Next Patent: LID, CUP CONTAINER, PACKAGE, AND PACKAGE WITH CONTENT THEREIN