TEST KIT FOR ANALYSING FACTOR VIII-SPLITTING PROTEASE

Title:

TEST KIT FOR ANALYSING FACTOR VIII-SPLITTING PROTEASE

Document Type and Number:

WIPO Patent Application WO2000050904

Kind Code:

A8

Abstract:

The invention relates to a test kit for analysing the von Willebrand factor-splitting protease and for carrying out differential diagnosis between patients with thrombotic thrombocytopenic purpura and patients with haemolytic-uraemic syndrome. Said test kit consists of a standard von Willebrand factor preparation which is free of von Willebrand factor-splitting activity, as a substrate for the von Willebrand factor-splitting activity in a sample or in the patient plasma, and a system for quantitatively determining the bonding of von Willebrand factor to collagen. The invention also relates to a method for detecting an acquired or congenital deficiency of von Willebrand factor-splitting protease.

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Inventors:

GERRITSEN HELENA E (CH)
FURLAN MIHA (CH)
TURECEK PETER (AT)
VARADI KATALIN (AT)
SIEKMANN JUERGEN (AT)
LAEMMLE BERNHARD (CH)
SCHWARZ HANS-PETER (AT)

Application Number:

PCT/AT2000/000049

Publication Date:

April 12, 2001

Filing Date:

February 23, 2000

Export Citation:

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Assignee:

BAXTER AG (AT)
GERRITSEN HELENA E (CH)
FURLAN MIHA (CH)
TURECEK PETER (AT)
VARADI KATALIN (AT)
SIEKMANN JUERGEN (AT)
LAEMMLE BERNHARD (CH)
SCHWARZ HANS PETER (AT)

International Classes:

C12Q1/37; G01N33/86; (IPC1-7): G01N33/86; C12Q1/37

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