Title:
TEST STRIP AND METHOD FOR DETERMINING HDL CHOLESTEROL CONCENTRATION FROM WHOLE BLOOD OF PLASMA
Document Type and Number:
WIPO Patent Application WO2003056163
Kind Code:
A9
Abstract:
A multilayer test strip [20] and method of using the test strip [20] for determining concentration of HDL cholesterol in a whole blood sample. The inventive test strip [20] includes a two-stage blood separation mechanism, including a first glass fiber matrix [38] which separates most of the blood cells and an adjacent, second matrix [40] preferably also containing glass fibers that separates the remainder of the blood cells. The second layer [40] also precipates and retains non-HDL cholesterol, thereby providing plasma that is substantially free of red blood cells and substantially free of non-HDL cholesterol to a reaction layer [42]. Precipitation and retention on non-HDLs takes place by vertical or dead-end filtration in a single layer [40]. The reaction layer [42] produces a color, the intensity of which is proportional to the concentration of HDL cholesterol in the blood sample which is applied to the test strip. Advantageously, the inventive test strip [20] is a vertical flow device, which can be made more compact and operates more efficiently than a lateral flow device.
Inventors:
SUNIL ANAOKAR
Application Number:
PCT/US2002/041075
Publication Date:
October 21, 2004
Filing Date:
December 23, 2002
Export Citation:
Assignee:
POLYMER TECHNOLOGY SYSTEMS INC (US)
SUNIL ANAOKAR
SUNIL ANAOKAR
International Classes:
G01N33/92; (IPC1-7): G01N33/92; G01N33/52; C12Q1/60
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