Title:
TETRACYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/143664
Kind Code:
A1
Abstract:
Provided is a therapeutic and preventive agent effective against diseases accompanied by an abnormality of ALK, such as cancers, cancerous metastases, depression, or cognitive dysfunction, the agent containing an ALK-inhibitory compound. The agent comprises a medicinal composition containing a compound represented by general formula (I) [with respect to the symbols in the formula, see the definitions given in the description], a salt of the compound, or a solvate of either.
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Inventors:
KINOSHITA KAZUTOMO (JP)
ASOH KOHSUKE (JP)
FURUICHI NORIYUKI (JP)
ITO TOSHIYA (JP)
KAWADA HATSUO (JP)
ISHII NOBUYA (JP)
SAKAMOTO HIROSHI (JP)
HONG WOOSANG (KR)
PARK MINJEONG (KR)
ONO YOSHIYUKI (JP)
KATO YASUHARU (JP)
MORIKAMI KENJI (JP)
EMURA TAKASHI (JP)
OIKAWA NOBUHIRO (JP)
ASOH KOHSUKE (JP)
FURUICHI NORIYUKI (JP)
ITO TOSHIYA (JP)
KAWADA HATSUO (JP)
ISHII NOBUYA (JP)
SAKAMOTO HIROSHI (JP)
HONG WOOSANG (KR)
PARK MINJEONG (KR)
ONO YOSHIYUKI (JP)
KATO YASUHARU (JP)
MORIKAMI KENJI (JP)
EMURA TAKASHI (JP)
OIKAWA NOBUHIRO (JP)
Application Number:
PCT/JP2010/059785
Publication Date:
December 16, 2010
Filing Date:
June 09, 2010
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KINOSHITA KAZUTOMO (JP)
ASOH KOHSUKE (JP)
FURUICHI NORIYUKI (JP)
ITO TOSHIYA (JP)
KAWADA HATSUO (JP)
ISHII NOBUYA (JP)
SAKAMOTO HIROSHI (JP)
HONG WOOSANG (KR)
PARK MINJEONG (KR)
ONO YOSHIYUKI (JP)
KATO YASUHARU (JP)
MORIKAMI KENJI (JP)
EMURA TAKASHI (JP)
OIKAWA NOBUHIRO (JP)
KINOSHITA KAZUTOMO (JP)
ASOH KOHSUKE (JP)
FURUICHI NORIYUKI (JP)
ITO TOSHIYA (JP)
KAWADA HATSUO (JP)
ISHII NOBUYA (JP)
SAKAMOTO HIROSHI (JP)
HONG WOOSANG (KR)
PARK MINJEONG (KR)
ONO YOSHIYUKI (JP)
KATO YASUHARU (JP)
MORIKAMI KENJI (JP)
EMURA TAKASHI (JP)
OIKAWA NOBUHIRO (JP)
International Classes:
C07D209/88; A61K31/343; A61K31/381; A61K31/403; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61P25/24; A61P25/28; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07D307/92; C07D333/76; C07D401/04; C07D401/06; C07D403/04; C07D405/12; C07D405/14; C07D471/04; C07D491/107
Domestic Patent References:
| WO2008051547A1 | 2008-05-02 | |||
| WO2009073620A2 | 2009-06-11 | |||
| WO2007023310A2 | 2007-03-01 | |||
| WO2006021884A2 | 2006-03-02 | |||
| WO2004080980A1 | 2004-09-23 | |||
| WO2009008371A1 | 2009-01-15 | |||
| WO2007130468A2 | 2007-11-15 | |||
| WO2005009389A2 | 2005-02-03 | |||
| WO2005097765A1 | 2005-10-20 | |||
| WO2008021369A2 | 2008-02-21 | |||
| WO2009013126A1 | 2009-01-29 |
Foreign References:
| JPH0892090A | 1996-04-09 |
Other References:
PROC NATL ACAD SCI USA, vol. 101, 2004, pages 13306 - 13311
NATURE, vol. 448, 2007, pages 561 - 566
BLOOD, vol. 72, 1988, pages 234 - 240
CANCER RES, vol. 59, 1999, pages 2776 - 2780
WORLD J GASTROENTEROL, vol. 12, 2006, pages 7104 - 7112
NATURE, vol. 455, 2008, pages 930 - 935
NATURE, vol. 455, 2008, pages 971 - 974
J BIOL CHEM, vol. 276, 2001, pages 16772 - 16779
J BIOL CHEM, vol. 277, 2002, pages 35990 - 35999
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
PROC AM ASSOC CANCER RES (AACR, vol. 47, 2006, pages LB-271
PROC AM ASSOC CANCER RES (AACR, vol. 47, 2006, pages LB-273
PROC NATL ACAD SCI USA, vol. 104, 2007, pages 270 - 275
CURRENT ORGANIC CHEMISTRY, vol. 5, no. 5, 2001, pages 507 - 518
CURRENT MEDICINAL CHEMISTRY: ANTI-CANCER AGENTS, vol. 4, no. 2, 2004, pages 149 - 172
GREENE, WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 23, 1993, pages 10628 - 36
ORGANIC LETTERS, vol. 9, no. 24, 2007, pages 5027 - 5029
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 2, 1991, pages 321 - 3
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 2008, pages 6479 - 6481
ORGANIC LETTERS, vol. 8, no. 3, 2006, pages 367 - 370
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 13, 2008, pages 3814 - 3824
J. ORG. CHEM., vol. 72, no. 25, 2007, pages 9541 - 9549
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pages 3449 - 3462
TETRAHEDRON LETT., 1977, pages 3529
J. AM. CHEM. SOC, vol. 99, 1977, pages 2353
J. AM. CHEM. SOC., vol. 122, 2000, pages 712 - 713
ORG. LETT, vol. 10, no. 8, 2008, pages 1545
J. ORG. CHEM., vol. 68, 2003, pages 8003
ANGEW. CHEM. INT. ED., vol. 42, 2003, pages 5051
TETRAHEDRON, vol. 64, no. 36, 2008, pages 8464 - 8475
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 2, 2008, pages 749 - 754
J. CHEM. SOC. PERKIN TRANS., vol. 1, 1988, pages 2345 - 2352
SYNTHESIS, 1993, pages 290 - 292
SYNTHESIS, 2004, pages 2629 - 2632X
SYNLETT, 2004, pages 883 - 885
TETRAHEDRON, vol. 38, no. 23, 1982, pages 3479 - 83
JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 14, 2007, pages 5337 - 5341
SYNTHESIS, 2008, pages 2943 - 2952
TETRAHEDRON, vol. 64, no. 40, 2008, pages 9607 - 9618
ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 2, 2005, pages 213 - 215
JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 19, 1993, pages 5209 - 5220
GAZZETTA CHIMICA ITALIANA, vol. 12 1, no. 11, 1991, pages 499 - 504
SYNLETT, 2008, pages 2689 - 2691
HETEROCYCLES, vol. 51, 1999, pages 2127
JOURNAL OF ORGANIC CHEMISTRY, vol. 72, 2007, pages 9329 - 9334
ORGANIC LETTERS, vol. 10, no. 4, 2008, pages 625 - 628
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 15, 2003, pages 6011 - 6019
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, pages 3977 - 3980
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 47, no. 38, 2008, pages 7230 - 7233
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 2, 2008, pages 568 - 570
ORGANIC LETTERS, vol. 11, no. 1, 2009, pages 221 - 224
J. AM. CHEM. SOC., vol. 122, 2000, pages 1360 - 1370
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 25, 2003, pages 9865 - 9866
ACTA PHARMACEUTICA HUNGARICA, vol. 73, no. 3, 2003, pages 171 - 178
HETEROCYCLES, vol. 26, no. 7, 1987, pages 1863 - 71
SYNTHESIS, 1988, pages 155 - 7
JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 19, 2008, pages 7785 - 7788
"e-EROS Encyclopedia of Reagents for Organic Synthesis", 2001
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 23, 2008, pages 7286 - 7299
MITSUNOBU, SYNTHESIS, vol. 1, 1981, pages 1
TETRAHEDRON, vol. 63, no. 43, 2007, pages 10671 - 10683
ORGANIC LETTERS, vol. 10, no. 23, 2008, pages 5325 - 5328
TETRAHEDRON LETTERS, vol. 49, no. 32, 2008, pages 4693 - 4694
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 13, 2008, pages 6489 - 6500
JOURNAL OF ORGANIC CHEMISTRY, 2003, pages 115
See also references of EP 2441753A4
NATURE, vol. 448, 2007, pages 561 - 566
BLOOD, vol. 72, 1988, pages 234 - 240
CANCER RES, vol. 59, 1999, pages 2776 - 2780
WORLD J GASTROENTEROL, vol. 12, 2006, pages 7104 - 7112
NATURE, vol. 455, 2008, pages 930 - 935
NATURE, vol. 455, 2008, pages 971 - 974
J BIOL CHEM, vol. 276, 2001, pages 16772 - 16779
J BIOL CHEM, vol. 277, 2002, pages 35990 - 35999
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
PROC AM ASSOC CANCER RES (AACR, vol. 47, 2006, pages LB-271
PROC AM ASSOC CANCER RES (AACR, vol. 47, 2006, pages LB-273
PROC NATL ACAD SCI USA, vol. 104, 2007, pages 270 - 275
CURRENT ORGANIC CHEMISTRY, vol. 5, no. 5, 2001, pages 507 - 518
CURRENT MEDICINAL CHEMISTRY: ANTI-CANCER AGENTS, vol. 4, no. 2, 2004, pages 149 - 172
GREENE, WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 23, 1993, pages 10628 - 36
ORGANIC LETTERS, vol. 9, no. 24, 2007, pages 5027 - 5029
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 2, 1991, pages 321 - 3
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 2008, pages 6479 - 6481
ORGANIC LETTERS, vol. 8, no. 3, 2006, pages 367 - 370
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 13, 2008, pages 3814 - 3824
J. ORG. CHEM., vol. 72, no. 25, 2007, pages 9541 - 9549
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pages 3449 - 3462
TETRAHEDRON LETT., 1977, pages 3529
J. AM. CHEM. SOC, vol. 99, 1977, pages 2353
J. AM. CHEM. SOC., vol. 122, 2000, pages 712 - 713
ORG. LETT, vol. 10, no. 8, 2008, pages 1545
J. ORG. CHEM., vol. 68, 2003, pages 8003
ANGEW. CHEM. INT. ED., vol. 42, 2003, pages 5051
TETRAHEDRON, vol. 64, no. 36, 2008, pages 8464 - 8475
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 2, 2008, pages 749 - 754
J. CHEM. SOC. PERKIN TRANS., vol. 1, 1988, pages 2345 - 2352
SYNTHESIS, 1993, pages 290 - 292
SYNTHESIS, 2004, pages 2629 - 2632X
SYNLETT, 2004, pages 883 - 885
TETRAHEDRON, vol. 38, no. 23, 1982, pages 3479 - 83
JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 14, 2007, pages 5337 - 5341
SYNTHESIS, 2008, pages 2943 - 2952
TETRAHEDRON, vol. 64, no. 40, 2008, pages 9607 - 9618
ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 2, 2005, pages 213 - 215
JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 19, 1993, pages 5209 - 5220
GAZZETTA CHIMICA ITALIANA, vol. 12 1, no. 11, 1991, pages 499 - 504
SYNLETT, 2008, pages 2689 - 2691
HETEROCYCLES, vol. 51, 1999, pages 2127
JOURNAL OF ORGANIC CHEMISTRY, vol. 72, 2007, pages 9329 - 9334
ORGANIC LETTERS, vol. 10, no. 4, 2008, pages 625 - 628
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 15, 2003, pages 6011 - 6019
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, pages 3977 - 3980
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 47, no. 38, 2008, pages 7230 - 7233
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 2, 2008, pages 568 - 570
ORGANIC LETTERS, vol. 11, no. 1, 2009, pages 221 - 224
J. AM. CHEM. SOC., vol. 122, 2000, pages 1360 - 1370
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 25, 2003, pages 9865 - 9866
ACTA PHARMACEUTICA HUNGARICA, vol. 73, no. 3, 2003, pages 171 - 178
HETEROCYCLES, vol. 26, no. 7, 1987, pages 1863 - 71
SYNTHESIS, 1988, pages 155 - 7
JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 19, 2008, pages 7785 - 7788
"e-EROS Encyclopedia of Reagents for Organic Synthesis", 2001
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 23, 2008, pages 7286 - 7299
MITSUNOBU, SYNTHESIS, vol. 1, 1981, pages 1
TETRAHEDRON, vol. 63, no. 43, 2007, pages 10671 - 10683
ORGANIC LETTERS, vol. 10, no. 23, 2008, pages 5325 - 5328
TETRAHEDRON LETTERS, vol. 49, no. 32, 2008, pages 4693 - 4694
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 13, 2008, pages 6489 - 6500
JOURNAL OF ORGANIC CHEMISTRY, 2003, pages 115
See also references of EP 2441753A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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